Evidence map›Paper›PMID 22045556›Full record

ReviewCellular and molecular life sciences : CMLS2012

Regulation of neutrophil trafficking from the bone marrow.

Ryan B Day, Daniel C Link

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Multi‑omics reveal neutrophil heterogeneity in sepsis (Review).International journal of molecular medicine · 2025
    Review
  3. Review
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  8. Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024
    Review
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ryan B DayDivision of Oncology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Daniel C Link

Funding

ROLE OF THE G-CSF RECEPTOR IN PROGENITOR MOBILIZATIONR01HL060772 · NHLBI · WASHINGTON UNIVERSITY · PI LINK, DANIEL C · 1999 to 2014
$3.9M
NHLBI NIH HHS R01 HL060772
6 · The paper itself

Abstract

Neutrophils are an essential component of the innate immune response and a major contributor to inflammation. Consequently, neutrophil homeostasis in the blood is highly regulated. Neutrophil number in the blood is determined by the balance between neutrophil production in the bone marrow and release from the bone marrow to blood with neutrophil clearance from the circulation. This review will focus on mechanisms regulating neutrophil release from the bone marrow. In particular, recent data demonstrating a central role for the chemokines CXCL12 and CXCL2 in regulating neutrophil egress from the bone marrow will be discussed.

Indexed as

AnimalsBone MarrowCell Adhesion MoleculesCell MovementHomeostasisHumansMiceModels, BiologicalNeutrophilsPeptide HydrolasesReceptors, CXCR4Receptors, Interleukin-8BSignal TransductionCell Adhesion MoleculesCXCR4 protein, humanCXCR4 protein, mousePeptide HydrolasesReceptors, CXCR4Receptors, Interleukin-8B

Identifiers

PMID22045556
PMCPMC11114822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.