ArticleJournal of magnetic resonance imaging : JMRI2012
In vivo assessment of neurodegeneration in Niemann-Pick type C mice by quantitative T2 mapping and diffusion tensor imaging.
Article in Journal of magnetic resonance imaging : JMRI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diffusion Tensor Imaging-Based Studies at the Group-Level Applied to Animal Models of Neurodegenerative Diseases.Frontiers in neuroscience · 2020Pooled it
- Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer's-like pathological dementia.GeroScience · 2024Article
- The Cerebellum in Niemann-Pick C1 Disease: Mouse Versus Man.Cerebellum (London, England) · 2023Review
- Longitudinal MEMRI analysis of brain phenotypes in a mouse model of Niemann-Pick Type C disease.NeuroImage · 2020Article
- Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid.The Journal of biological chemistry · 2020Article
- Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Tract-Specific White Matter Correlates of Age-Related Reward Devaluation Deficits in Macaque Monkeys.Journal of neuroimaging in psychiatry & neurology · 2018Article
- Early Hippocampal i-LTP and LOX-1 Overexpression Induced by Anoxia: A Potential Role in Neurodegeneration in NPC Mouse Model.International journal of molecular sciences · 2017Article
- Quantitative magnetic resonance imaging of brain atrophy in a mouse model of Niemann-Pick type C disease.PloS one · 2017Article
- Altered transition metal homeostasis in Niemann-Pick disease, type C1.Metallomics : integrated biometal science · 2014Article
- (1) H magnetic resonance spectroscopy of neurodegeneration in a mouse model of niemann-pick type C1 disease.Journal of magnetic resonance imaging : JMRI · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo quantitatively and noninvasively assess neurological disease progression in a mouse model of Niemann-Pick type C (NPC) disease by measuring white matter status with magnetic resonance imaging (MRI) techniques of T2 mapping and diffusion tensor imaging (DTI). MATERIALS AND
methodsQuantitative T2 and DTI experiments were performed in vivo in NPC disease model and control mice at three timepoints to quantify differences and changes in white matter with measurements of T2 relaxation and DTI parameters. Histological staining for myelin content was also performed at two timepoints to compare with the MRI findings.
resultsThe results of the T2 and DTI measurements show significant differences in white matter areas of the brain in the NPC disease model compared to control mice at several timepoints, and were seen to change over time in both groups.
conclusionThe findings of this study suggest that quantitative MRI measurements may be suitable in vivo biomarkers of disease status for future studies of NPC disease models. The changes in white matter measurements between timepoints in both control and NPC disease groups suggest that white matter structures continue to change and develop over time in the NPC model and can be tracked with MRI techniques.
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