ArticleEuropean journal of applied physiology2012
Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- Differences in handgrip strength protocols to identify sarcopenia and frailty - a systematic review.BMC geriatrics · 2017Pooled it
- Trial
- Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.European geriatric medicine · 2025Article
- ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults.International journal of environmental research and public health · 2021Article
- The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study.BMC musculoskeletal disorders · 2021Article
- Strength and Endurance Training in Older Women in Relation toInternational journal of environmental research and public health · 2020Article
- Review
- Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women.Clinical interventions in aging · 2017Article
- Article
- The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training.BMC geriatrics · 2013Article
- ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli.Age (Dordrecht, Netherlands) · 2013Article
- Genes for elite power and sprint performance: ACTN3 leads the way.Sports medicine (Auckland, N.Z.) · 2013Review
- Advances in exercise, fitness, and performance genomics in 2012.Medicine and science in sports and exercise · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the single and combined influence of the ACE I/D and the ACTN3 R577X polymorphisms on muscle phenotypes (thigh muscles' cross-sectional area assessed with magnetic resonance imaging) and strength (maximal handgrip, 30-s chair stand test), functional ability during activities of daily living (Barthel index) and bone mineral density (proximal femur) in Caucasian (Spanish) community-dwelling old people [n = 81, 59 women; mean age 82.8 ± 4.8 years (range 71-93 years)]. We found no significantly differences in the aforementioned phenotypes across ACE and ACTN3 genotypes (all P > 0.05), except for handgrip in the ACE I/D recessive model (DD 19.5 ± 6.7 kg, ID 24.0 ± 9.1 kg, II 22.1 ± 7.9; P = 0.047), yet statistical significance disappeared after correction for multiple comparisons. Likewise, the analyses of the combined effects between genotypes did not yield any significant difference (all P > 0.05) between the two 'extreme' genotypes [theoretically 'power or muscularity oriented' [(ACTN3 RR + RX & ACE DD) versus 'non-power' (ACTN3 XX & ACE II + ID)]. The aforementioned analyses were adjusted by sex, age and physical activity levels as covariates. Logistic regression analysis revealed no significant association of single or combined effect of ACE and ACTN3 genotypes or genotype combination group (ACE + ACTN3) with sarcopenia (i.e. being in the lowest 25th sex-specific percentile for a combined score of the muscle and functional phenotypes we measured). Though ACE I/D and ACTN3 R577X polymorphisms are candidates to modulate exercise-related phenotypes in adults, our data suggest that they do not exert a major influence in the muscle phenotypes of old people. More studies with larger sample sizes are needed.
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