ArticleHeredity2012
Evolution of adaptive phenotypic traits without positive Darwinian selection.
Article in Heredity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Genomic and transcriptomic analyses reveal the adaptation to semi-aquatic and aquatic life in spiders.Molecular biology and evolution · 2026Article
- Article
- Natural selection on apical membrane antigen 1 (AMA1) of an emerging zoonotic malaria parasite Plasmodium inui.Scientific reports · 2024Article
- One Cell, Two Gears: Extensive Somatic Genome Plasticity Accompanies High Germline Genome Stability in Paramecium.Genome biology and evolution · 2021Article
- Bridging Tumorigenesis and Therapy Resistance With a Non-Darwinian and Non-Lamarckian Mechanism of Adaptive Evolution.Frontiers in oncology · 2021Article
- Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.Open biology · 2020Article
- No evidence for local adaptation and an epigenetic underpinning in native and non-native ruderal plant species in Germany.Ecology and evolution · 2019Article
- Review
- Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.Chembiochem : a European journal of chemical biology · 2017Article
- The waiting time problem in a model hominin population.Theoretical biology & medical modelling · 2015Article
- Towards the identification of the loci of adaptive evolution.Methods in ecology and evolution · 2015Review
- Social parasitism and the molecular basis of phenotypic evolution.Frontiers in genetics · 2015Article
- Evolutionary ecology of the marine Roseobacter clade.Microbiology and molecular biology reviews : MMBR · 2014Review
- Natural selection on coding and noncoding DNA sequences is associated with virulence genes in a plant pathogenic fungus.Genome biology and evolution · 2014Article
- Evolutionary constraints or opportunities?Bio Systems · 2014Article
- Evidence for adaptive evolution of low-temperature stress response genes in a Pooideae grass ancestor.The New phytologist · 2013Article
- Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The branch-site test of positive selection is surprisingly robust but lacks power under synonymous substitution saturation and variation in GC.Molecular biology and evolution · 2013Article
- Transcriptome analyses of primitively eusocial wasps reveal novel insights into the evolution of sociality and the origin of alternative phenotypes.Genome biology · 2013Article
- Dangers of 'adaptation'.Heredity · 2012Article
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Abstract
Recent evidence suggests the frequent occurrence of a simple non-Darwinian (but non-Lamarckian) model for the evolution of adaptive phenotypic traits, here entitled the plasticity-relaxation-mutation (PRM) mechanism. This mechanism involves ancestral phenotypic plasticity followed by specialization in one alternative environment and thus the permanent expression of one alternative phenotype. Once this specialization occurs, purifying selection on the molecular basis of other phenotypes is relaxed. Finally, mutations that permanently eliminate the pathways leading to alternative phenotypes can be fixed by genetic drift. Although the generality of the PRM mechanism is at present unknown, I discuss evidence for its widespread occurrence, including the prevalence of exaptations in evolution, evidence that phenotypic plasticity has preceded adaptation in a number of taxa and evidence that adaptive traits have resulted from loss of alternative developmental pathways. The PRM mechanism can easily explain cases of explosive adaptive radiation, as well as recently reported cases of apparent adaptive evolution over ecological time.
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