ArticleAIDS (London, England)2012
Clinical, virologic, and immunologic correlates of HIV-1 intraclade B dual infection among men who have sex with men.
Article in AIDS (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Quantifying prevalence and risk factors of HIV multiple infection in Uganda from population-based deep-sequence data.PLoS pathogens · 2025Article
- Nanopore Sequencing for Characterization of HIV-1 Recombinant Forms.Microbiology spectrum · 2022Article
- Full-Length Envelope Analyzer (FLEA): A tool for longitudinal analysis of viral amplicons.PLoS computational biology · 2018Article
- Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.Nature communications · 2018Article
- Article
- Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response.Journal of virology · 2017Article
- Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.AIDS (London, England) · 2017Article
- Article
- HIV-associated neurocognitive disorder is associated with HIV-1 dual infection.AIDS (London, England) · 2016Article
- Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy.Virus evolution · 2016Article
- Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.PLoS pathogens · 2016Article
- Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages.PloS one · 2016Article
- HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression.Scientific reports · 2015Article
- HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing.Virology · 2015Article
- HIV-1 superinfection is associated with an accelerated viral load increase but has a limited impact on disease progression.AIDS (London, England) · 2014Article
- Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.Retrovirology · 2014Article
- Incidence and prevalence of intrasubtype HIV-1 dual infection in at-risk men in the United States.The Journal of infectious diseases · 2014Article
- Dynamics of viral evolution and neutralizing antibody response after HIV-1 superinfection.Journal of virology · 2013Article
- Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection.The Journal of infectious diseases · 2013Article
- Frequency and implications of HIV superinfection.The Lancet. Infectious diseases · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the susceptibilities to and consequences of HIV-1 dual infection.
designWe compared clinical, virologic, and immunologic factors between participants who were dually infected with HIV-1 subtype B and monoinfected controls who were matched by ongoing HIV risk factor.
methodsThe viral load and CD4 progressions of dually and singly infected participant groups were compared with linear mixed-effects models, and individual dynamics before and after superinfection were assessed with a structural change test (Chow test). Recombination breakpoint analysis (GARD), HLA frequency analysis, and cytotoxic T-lymphocyte (CTL) epitope mapping were also performed (HIV LANL Database).
resultsThe viral loads of dually infected participants increased more over 3 years of follow-up than the viral loads of monoinfected controls, whereas CD4 progressions of the two groups did not differ. Viral escape from CTL responses following superinfection was observed in two participants whose superinfecting strain completely replaced the initial strain. This pattern was not seen among participants whose superinfecting virus persisted in a recombinant form with the initial virus or was only detected transiently. Several HLA types were over-represented in dually infected participants as compared to monoinfected controls.
conclusionsThese results identify potential factors for dual infection susceptibility and further define its clinical consequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.