ArticleThe Journal of membrane biology2011
Mitochondrial permeability transition induced by different concentrations of zinc.
Article in The Journal of membrane biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Long-term exposure to PMScientific reports · 2024Article
- The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction.Biomedicines · 2021Review
- Mitochondrial morphology and function impaired by dimethyl sulfoxide and dimethyl Formamide.Journal of bioenergetics and biomembranes · 2018Article
- Silver ion-induced mitochondrial dysfunctionToxicology research · 2017Article
- Spectroscopic, Polarographic, and Microcalorimetric Studies on Mitochondrial Dysfunction Induced by Ethanol.The Journal of membrane biology · 2017Article
- Size Effects on the Interaction of QDs with the Mitochondrial Membrane In Vitro.The Journal of membrane biology · 2016Article
- Rat Liver Mitochondrial Dysfunction Induced by an Organic Arsenical Compound 4-(2-Nitrobenzaliminyl) Phenyl Arsenoxide.The Journal of membrane biology · 2015Article
- Spectroscopic and Microscopic Studies on the Mechanism of Mitochondrial Toxicity Induced by CdTe QDs Modified with Different Ligands.The Journal of membrane biology · 2015Article
- Nd(III)-induced rice mitochondrial dysfunction investigated by spectroscopic and microscopic methods.The Journal of membrane biology · 2015Article
- Interaction of one anthraquinone derivative with ctDNA analyzed by spectroscopic and modeling methods.Journal of fluorescence · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is one of the required trace elements in animals, and it serves an important role in biological systems. However, high levels of zinc are poisonous to organisms. So far, there exist conflicting reports about zinc ions-induced mitochondrial permeability transition (MPT). We analyzed the effects of Zn²⁺ on MPT by monitoring mitochondrial swelling with the ultraviolet-visible light absorption spectrum, characterizing the fluidity of the membrane with fluorescence anisotropy, detecting the transmembrane potential (Δψ) with fluorescence intensity, and observing mitochondrial ultrastructure with transmission electron microscopy. Data reveal that low concentrations of zinc ions can trigger MPT while high levels of zinc ions cannot, which implies that zinc ions' toxicity cannot be the result of a single simple mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.