Evidence map›Paper›PMID 22045273›Full record

ReviewJournal of gastrointestinal cancer2012

Dietary, endocrine, and metabolic factors in the development of colorectal cancer.

Michele Barone, Katia Lofano, Nicola De Tullio, Raffaele Licinio, Raffaele Licino, Francesca Albano, Alfredo Di Leo

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of gastrointestinal cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Curcumin and Colorectal Cancer: From Basic to Clinical Evidences.International journal of molecular sciences · 2020
    Review
  10. Article
  11. Review
  12. Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.International journal of molecular sciences · 2017
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Oestrogen and colorectal cancer: mechanisms and controversies.International journal of colorectal disease · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
    Licino, Raffaele [corrected to Licinio, Raffaele]
5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michele BaroneDepartment of Emergency and Organ Transplantation, Section of Gastroenterology, Bari, Italy.
Katia Lofano
Nicola De Tullio
Raffaele Licinio
Raffaele Licino
Francesca Albano
Alfredo Di Leo
University Gastroenterology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColorectal cancer is the third cause of death in industrialized countries. Genetic susceptibility and diet are determinant of cancer risk and tumor behavior. Variation in cancer incidence among and within populations with similar dietary patterns suggests that an individual response may reflect interactions with genetic factors, which may modify gene, protein, and metabolite expression patterns. Nutrigenomics, defined as the interaction between nutrition and an individual genome, will likely provide important clues about responders and non-responders to nutritional intervention. DISCUSSION: Epidemiological and experimental studies suggest a protective role of some normal components of daily diet (fish oil, milk, and vegetables), estrogens, and phytoestrogens in colorectal cancer. The effect of estrogen seems to be mediated by their binding to estrogen receptor beta (ER-β), one of the two estrogen receptors with high affinity for these hormones. Very recently, the demonstration of an involvement of ER-β in the development of adenomatous polyps of the colon has also been documented, suggesting the use of selective ER-β agonists in primary colorectal cancer prevention. Phytoestrogens are plant-derived compounds that structurally and functionally act as estrogen agonists in mammals. They are characterized by a higher binding affinity to ER-β as compared to estrogen receptor alpha (ER-α), the other estrogen receptor subtype. These biological characteristics explain why the administration of phytoestrogens does not produce the classical side effects associated to estrogen administration (cerebro- and cardiovascular accidents, higher incidence of endometrial and breast cancer) and makes these substances potential candidates for colorectal cancer prevention.

Indexed as

DietAnimalsCalcium, DietaryColorectal NeoplasmsEstrogen Receptor betaFishesHumansMeatMilkObesityPhytoestrogensVegetablesCalcium, DietaryEstrogen Receptor betaPhytoestrogens

Identifiers

PMID22045273
OpenAlexW2006601064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.