ArticleBritish journal of cancer2011
Rapid in vivo testing of drug response in multiple myeloma made possible by xenograft to turkey embryos.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells.International journal of molecular medicine · 2018Article
- Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.Oncotarget · 2017Article
- Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo.Leukemia · 2015Article
- Establishment of a human multiple myeloma xenograft model in the chicken to study tumor growth, invasion and angiogenesis.Journal of visualized experiments : JoVE · 2015Article
- Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma.Current cancer drug targets · 2012Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe best current xenograft model of multiple myeloma (MM) in immune-deficient non-obese diabetic/severe-combined immunodeficient mice is costly, animal maintenance is complex and several weeks are required to establish engraftment and study drug efficacy. More practical in vivo models may reduce time and drug development cost. We recently described a rapid low-cost xenograft model of human blood malignancies in pre-immune turkey. Here, we report application of this system for studying MM growth and the preclinical assessment of anticancer therapies.
methodsCell lines and MM patient cells were injected intravenously into embryonic veins on embryonic day 11 (E11). Engraftment of human cells in haematopoietic organs was detected by quantitative real-time polymerase chain reaction, immunohistochemistry, flow cytometry and circulating free light chain.
resultsEngraftment was detected after 1 week in all embryos injected with cell lines and in 50% of those injected with patient cells. Injection of bortezomib or lenalinomide 48 h after cell injection at therapeutic levels that were not toxic to the bone marrow dramatically reduced MM engraftment.
conclusionThe turkey embryo provides a practical, xenograft system to study MM and demonstrates the utility of this model for rapid and affordable testing therapeutics in vivo. With further development, this model may enable rapid, inexpensive personalised drug screening.
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