ArticleNature communications2011
Large-scale DNA editing of retrotransposons accelerates mammalian genome evolution.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Genome sequencing of3 Biotech · 2024Article
- The Intricate Interplay between APOBEC3 Proteins and DNA Tumour Viruses.Pathogens (Basel, Switzerland) · 2024Review
- The coevolution between APOBEC3 and retrotransposons in primates.Mobile DNA · 2022Review
- On the Base Composition of Transposable Elements.International journal of molecular sciences · 2022Review
- Activation of Endogenous Retrovirus, Brain Infections and Environmental Insults in Neurodegeneration and Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.Nucleic acids research · 2021Article
- Retrotransposons as Drivers of Mammalian Brain Evolution.Life (Basel, Switzerland) · 2021Review
- The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.Open biology · 2020Article
- Variation in base composition underlies functional and evolutionary divergence in non-LTR retrotransposons.Mobile DNA · 2020Article
- Endogenous retroviruses are associated with hippocampus-based memory impairment.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- All I's on the RADAR: role of ADAR in gene regulation.FEBS letters · 2018Review
- Transposable Elements Activity is Positively Related to Rate of Speciation in Mammals.Journal of molecular evolution · 2018Article
- Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H.Scientific reports · 2017Article
- The preferred nucleotide contexts of the AID/APOBEC cytidine deaminases have differential effects when mutating retrotransposon and virus sequences compared to host genes.PLoS computational biology · 2017Article
- Is Tolerance Broken in Autoimmunity?Clinical medicine insights. Pathology · 2017Article
- Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity.Genome research · 2016Article
- DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes.Molecular biology and evolution · 2016Article
- Restricting retrotransposons: a review.Mobile DNA · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retrotransposons had an important role in genome evolution, including the formation of new genes and promoters and the rewiring of gene networks. However, it is unclear how such a repertoire of functions emerged from a relatively limited number of source sequences. Here we show that DNA editing, an antiviral mechanism, accelerated the evolution of mammalian genomes by large-scale modification of their retrotransposon sequences. We find numerous pairs of retrotransposons containing long clusters of G-to-A mutations that cannot be attributed to random mutagenesis. These clusters, which we find across different mammalian genomes and retrotransposon families, are the hallmark of APOBEC3 activity, a potent antiretroviral protein family with cytidine deamination function. As DNA editing simultaneously generates a large number of mutations, each affected element begins its evolutionary trajectory from a unique starting point, thereby increasing the probability of developing a novel function. Our findings thus suggest a potential mechanism for retrotransposon domestication.
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