Evidence map›Paper›PMID 22044698›Full record

ArticleCell communication and signaling : CCS2011

"Targeted disruption of the epithelial-barrier by Helicobacter pylori".

Lydia E Wroblewski, Richard M Peek

Open access · goldAbstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 59 citations in OpenAlex.

  1. Frontiers in cell and developmental biology · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Effects ofFrontiers in immunology · 2023
    Review
  6. The synergistic effect ofFrontiers in cellular and infection microbiology · 2023
    Article
  7. Article
  8. Review
  9. Dual infective burden of Helicobacter pylori and intestinal parasites: Good or bad news for the host?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Review
  10. T Cell Cytokines Impact Epithelial Cell Responses duringJournal of immunology (Baltimore, Md. : 1950) · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prevalence ofAnnals of medicine and surgery (2012) · 2018
    Article
  16. World journal of gastroenterology · 2018
    Review
  17. Article
  18. Article
  19. Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma.World journal of gastrointestinal pathophysiology · 2016
    Review
  20. Dysbiotic infection in the stomach.World journal of gastroenterology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Lydia E WroblewskiDivision of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Lydia.Wroblewski@vanderbilt.edu.
Richard M Peek
Nashville VA Medical Center · USVanderbilt University Medical Center · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
6 · The paper itself

Abstract

Helicobacter pylori colonizes the human gastric epithelium and induces chronic gastritis, which can lead to gastric cancer. Through cell-cell contacts the gastric epithelium forms a barrier to protect underlying tissue from pathogenic bacteria; however, H. pylori have evolved numerous strategies to perturb the integrity of the gastric barrier. In this review, we summarize recent research into the mechanisms through which H. pylori disrupts intercellular junctions and disrupts the gastric epithelial barrier.

Identifiers

PMID22044698
PMCPMC3225297
OpenAlexW2134355667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.