ArticleCell communication and signaling : CCS2011
H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection.
Article in Cell communication and signaling : CCS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- [Molecular mechanisms of chronic gastric mucosal inflammation induced byZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- A vicious cycle inducer in gastric pathogenesis: implication of Helicobacter pylori.Archives of microbiology · 2026Review
- Mucosal vaccination with enzymatically activeFrontiers in microbiology · 2026Article
- Nanoemulsion as a promising drug delivery strategy for effective eradication of Helicobacter pylori: current insights.Drug delivery and translational research · 2026Review
- Navigating the gastric frontier of mucosal immunity againstFrontiers in immunology · 2026Review
- Effect ofImmunotherapy · 2025Review
- Bacteria and Allergic Diseases.International journal of molecular sciences · 2024Review
- Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review.Tropical medicine and infectious disease · 2024Review
- Review
- TLR9 and Glioma: Friends or Foes?Cells · 2022Review
- Incorporating Immunotherapy in the Management of Gastric Cancer: Molecular and Clinical Implications.Cancers · 2022Review
- The bacterial microbiota regulates normal hematopoiesis via metabolite-induced type 1 interferon signaling.Blood advances · 2022Article
- Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer.International journal of molecular sciences · 2022Review
- Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling.Journal of immunology research · 2022Article
- The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022Review
- Gastric Microenvironment-A Partnership between Innate Immunity and Gastric Microbiota TricksJournal of clinical medicine · 2021Review
- Article
- Priming the seed:World journal of gastrointestinal oncology · 2018Review
- The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent infection with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes carriers to a high gastric cancer risk, but has also been linked to protection from allergic, chronic inflammatory and autoimmune diseases. In the course of tens of thousands of years of co-existence with its human host, H. pylori has evolved elaborate adaptations that allow it to persist in the hostile environment of the stomach in the face of a vigorous innate and adaptive immune response. For this review, we have identified several key immune cell types and signaling pathways that appear to be preferentially targeted by the bacteria to establish and maintain persistent infection. We explore the mechanisms that allow the bacteria to avoid detection by innate immune cells via their pattern recognition receptors, to escape T-cell mediated adaptive immunity, and to reprogram the immune system towards tolerance rather than immunity. The implications of the immunomodulatory properties of the bacteria for the prevention of allergic and auto-immune diseases in chronically infected individuals are also discussed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.