ArticleStress (Amsterdam, Netherlands)2012
Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.
Article in Stress (Amsterdam, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment.Psychological medicine · 2024Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Respiration rate during a stress task moderates neuroticism and perceived stress in older adults.Current issues in personality psychology · 2022Article
- Moderating role of observing the five precepts of Buddhism on neuroticism, perceived stress, and depressive symptoms.PloS one · 2022Article
- Role of Equanimity on the Mediation Model of Neuroticism, Perceived Stress and Depressive Symptoms.Healthcare (Basel, Switzerland) · 2021Article
- The role of perceived stress and cognitive function on the relationship between neuroticism and depression among the elderly: a structural equation model approach.BMC psychiatry · 2020Article
- Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.Current neuropharmacology · 2018Review
- Effects of stressful life events on cerebral white matter hyperintensity progression.International journal of geriatric psychiatry · 2017Article
- Epigenetic programming by stress and glucocorticoids along the human lifespan.Molecular psychiatry · 2017Article
- Heterogeneity in the three-year course of major depression among older adults.International journal of geriatric psychiatry · 2016Article
- Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.Genome biology · 2015Article
- The Interplay of Genetics, Behavior, and Pain with Depressive Symptoms in the Elderly.The Gerontologist · 2015Article
- Gene-environment interaction in major depression: focus on experience-dependent biological systems.Frontiers in psychiatry · 2015Review
- Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression.Journal of psychiatric research · 2013Article
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
Although the relation between stressful life events (SLEs) and risk of major depressive disorder is well established, important questions remain about the effects of stress on the course of geriatric depression. Our objectives were (1) to examine how baseline stress and change in stress is associated with course of geriatric depression and (2) to test whether polymorphisms of serotonin transporter (5-HTTLPR) and catechol-O-methyltransferase (COMT Val158Met) genes moderate this relation. Two-hundred and sixteen depressed subjects aged 60 years or older were categorized by remission status (Montgomery-Asberg depression rating scale≤6) at 6 and 12 months. At 6 months, greater baseline numbers of self-reported negative and total SLEs and greater baseline perceived stress severity were associated with lower odds of remission. At 12 months, only baseline perceived stress predicted remission. When we examined change in stress, 12-month decrease in negative SLEs and level of perceived stress were associated with improved odds of 12-month remission. When genotype data were included, COMT Val158Met genotype did not influence these relations. However, when compared with 5-HTTLPR L/L homozygotes, S allele carriers with greater baseline numbers of negative SLEs and with greater decrease in negative SLEs were more likely to remit at 12 months. This study demonstrates that baseline SLEs and perceived stress severity may influence the 12-month course of geriatric depression. Moreover, changes in these stress measures over time correlate with depression outcomes. 5-HTTLPR S carriers appear to be more susceptible to both the effects of enduring stress and the benefit of interval stress reduction.
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