ArticleImmunology2011
γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine.
Article in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Gut microbiota translocation and dissemination in health: can it be beneficial and purposeful?Gut microbes · 2026Review
- Ligands for Intestinal Intraepithelial T Lymphocytes in Health and Disease.Pathogens (Basel, Switzerland) · 2025Review
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- "Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity".Mucosal immunology · 2022Review
- Food for thought - ILC metabolism in the context of helminth infections.Mucosal immunology · 2022Review
- IL-27 Enhances γδ T Cell-Mediated Innate Resistance to Primary Hookworm Infection in the Lungs.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity.Frontiers in immunology · 2022Review
- Unconventional Intestinal Intraepithelial Lymphocytes in Health and Disease.Critical reviews in immunology · 2021Review
- Adults from Kisumu, Kenya have robust γδ T cell responses to Schistosoma mansoni, which are modulated by tuberculosis.PLoS neglected tropical diseases · 2020Article
- Recent advances in roles of G-protein coupled receptors in intestinal intraepithelial lymphocytes.Bioscience of microbiota, food and health · 2020Review
- Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier.Trends in immunology · 2018Review
- Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- An Insight Into the Intestinal Web of Mucosal Immunity, Microbiota, and Diet in Inflammation.Frontiers in immunology · 2018Review
- Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease.Frontiers in immunology · 2018Article
- Contributions of Farm Animals to Immunology.Frontiers in veterinary science · 2018Review
- IL-33 Drives Augmented Responses to Ozone in Obese Mice.Environmental health perspectives · 2017Article
- Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response from Type 1 to Type 2.American journal of respiratory cell and molecular biology · 2016Article
- γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice.PloS one · 2015Article
- Immunity to gastrointestinal nematodes: mechanisms and myths.Immunological reviews · 2014Review
- Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.Oncogene · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The intestinal epithelium is rich in γδ T cells and the gut is a site of residence for a wide variety of pathogens, including nematodes. Although CD4+ T-cell receptor (TCR) -αβ+ T helper type 2 T cells are essential for the expulsion of intestinal nematodes, little information is available on the function of γδ T cells in this type of infection. Here, we demonstrate two major functions of γδ T cells as a potently protective T-cell population against Nippostrongylus brasiliensis infection using γδ T-cell-deficient (TCR-δ(-/-) ) mice. First, γδ T cells are required to initiate rapid expulsion of adult worms from the intestine and to limit egg production. Second, γδ T cells prevent the pathological intestinal damage associated with nematode infection, evident by increased clinical disease and more severe microscopic lesions in infected TCR-δ(-/-) mice. γδ T-cell deficiency led to delayed goblet cell hyperplasia in association with reduced expression of phosphorylated STAT6, MUC2, Trefoil factor-3 (TFF3) and T helper type 2 cytokines including interleukin-13 (IL-13). TCR-δ(-/-) mice also produced more interferon-γ than wild-type mice. Within the intraepithelial lymphocyte compartment, γδ T cells produced IL-13. Adoptive transfer of γδ T cells or administration of recombinant IL-13 to TCR-δ(-/-) mice successfully reduced the egg production by N. brasiliensis. Collectively, these data provide strong evidence that γδ T cells play an important role in controlling infection with intestinal nematodes and limiting infection-induced pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.