Evidence map›Paper›PMID 22044202›Full record

ReviewFuture oncology (London, England)2011

MRI of metastasis-permissive microenvironments.

Marie-France Penet, Zhihang Chen, Zaver M Bhujwalla

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Metabolic requirements of the metastatic cascade.Current opinion in systems biology · 2021
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Imaging the Tumor Microenvironment.Cancer journal (Sudbury, Mass.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marie-France PenetJHU In vivo Cellular & Molecular Imaging Center, The Russell H. Morgan Department of Radiology & Radiological Science, Baltimore, MD, USA. mpenet@mri.jhu.edu
Zhihang Chen
Zaver M Bhujwalla

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Theranostic Imaging of Metastatic Prostate CancerP50CA103175 · NCI · JOHNS HOPKINS UNIVERSITY · PI BARKER, PETER B · 2003 to 2015
$17.9M
Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancerR01CA138264 · NCI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2009 to 2023
$8.1M
HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASISR01CA082337 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1999 to 2024
$5.1M
FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPER01CA073850 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1997 to 2014
$3.5M
Imaging Hypoxia and Cancer Stem CellsR01CA136576 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2017
$2.4M
Image-guided Prodrug and siRNA Targeting of CancerR01CA138515 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 2009 to 2013
$1.7M
NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA103175NCI NIH HHS R01 CA073850NCI NIH HHS R01 CA082337NCI NIH HHS R01 CA136576NCI NIH HHS R01 CA138264NCI NIH HHS R01 CA138515NCI NIH HHS R01 CA138515NCI NIH HHS R01 CA73850NCI NIH HHS R01 CA82337
6 · The paper itself

Abstract

One of the earliest documented observations of the importance of the microenvironment in metastasis was made by Stephen Paget in 1889. More than a century later, the metastatic cascade remains a major cause of mortality from cancer. Cancer meets the criterion of a successful organization that is able to survive by adapting to changing environments. In fact, the tumor microenvironment and stroma are co-opted and shaped by cancer cells to derive a survival advantage. Cohesive strategies integrating advances in molecular biology and chemistry, with noninvasive multimodality imaging, provide new insights into the role of the tumor microenvironment in promoting metastasis from primary tumors as well as insights into environments that attract and permit cancer cells to establish colonies in distant organs. This article provides an overview of molecular and functional imaging characterization of microenvironments that can promote or permit cancer cells to metastasize and the microenvironmental characteristics of distant metastases.

Indexed as

Tumor MicroenvironmentAnimalsExtracellular MatrixHumansMagnetic Resonance ImagingMiceNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsNeovascularization, Pathologic

Identifiers

PMID22044202
PMCPMC3235911

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.