ArticleJournal of long-term effects of medical implants2011
Short-term and long-term effects of orthopedic biodegradable implants.
Article in Journal of long-term effects of medical implants, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Here today, gone tomorrow: the transformative role of biodegradable materials in modern trauma care.EFORT open reviews · 2026Pooled it
- Polydioxanone implants: A systematic review on safety and performance in patients.Journal of biomaterials applications · 2020Pooled it
- Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review.BMC musculoskeletal disorders · 2013Pooled it
- Corrosion Behavior of Ti-Nb-Zr-Si Alloy after One-Year Exposure to Simulated Inflammatory Conditions.ACS omega · 2026Article
- Investigating the Effects of Charge on the Release Kinetics of Charge-Modified Peptides from Gelatin Microparticles.Cell biomaterials · 2026Article
- Image-guided in vivo evaluation and comparison of bone-targeting peptides for therapeutic intervention.Drug delivery and translational research · 2026Article
- Synthetic Hydrogels Incorporating Hydrolytic/Nonhydrolytic Macromer Ratios Exhibit Improved Tunability of In Vivo Degradation and Immune Responses.Advanced healthcare materials · 2026Article
- Polymer-Based Resorbable vs Non-resorbable Implants for Pediatric Upper Extremity Fractures: A Systematic Review.Orthopedic reviews · 2026Article
- Advanced Biocompatible and Biodegradable Polymers: A Review of Functionalization, Smart Systems, and Sustainable Applications.Polymers · 2025Review
- Advances in applications of low-dimensional piezoelectric materials in musculoskeletal system.Materials today. Bio · 2025Review
- Review
- A Structural Optimization Framework for Biodegradable Magnesium Interference Screws.Biomimetics (Basel, Switzerland) · 2025Article
- Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration.Biomaterials research · 2025Review
- NOVEL HIGH-STRENGTH POLYESTER COMPOSITE SCAFFOLDS FOR BONE REGENERATION.Polymers for advanced technologies · 2023Article
- Biodegradable Polymers in Biomedical Applications: A Review-Developments, Perspectives and Future Challenges.International journal of molecular sciences · 2023Review
- Review
- Mechanism of remodeling and local effects in vivo of a new injectable cosmetic filler.Scientific reports · 2023Article
- Review
- Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering.Bioactive materials · 2023Article
- Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up.Bioactive materials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion market, a figure expected to experience significant and continued growth. Although traditional permanent implants have been proved clinically efficacious, they are also associated with several drawbacks, including secondary revision and removal surgeries. Non-permanent, biodegradable implants offer a promising alternative for patients, as they provide temporary support and degrade at a rate matching tissue formation, and thus, eliminate the need for secondary surgeries. These implants have been in clinical use for nearly 25 years, competing directly with, or maybe even exceeding, the performance of permanent implants. The initial implantation of biodegradable materials, as with permanent materials, mounts an acute host inflammatory response. Over time, the implant degradation profile and possible degradation product toxicity mediate long-term biodegradable implant-induced inflammation. However, unlike permanent implants, this inflammation is likely to cease once the material disappears. Implant-mediated inflammation is a critical determinant for implant success. Thus, for the development of a proactive biodegradable implant that has the ability to promote optimal bone regeneration and minimal detrimental inflammation, a thorough understanding of short- and long-term inflammatory events is required. Here, we discuss an array of biodegradable orthopedic implants, their associated short- and long- term inflammatory effects, and methods to mediate these inflammatory events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.