ReviewImmunology2011
CD4+ T helper 2 cells--microbial triggers, differentiation requirements and effector functions.
Review in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- The Role of Regnase-1 in Autoimmune Diseases - A Future Therapeutic Target for Clinical Use.Clinical reviews in allergy & immunology · 2026Review
- Review
- Establishment of a lncRNA-Based Prognostic Gene Signature Associated With Altered Immune Responses in HCC.Frontiers in immunology · 2022Article
- Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes.Immune network · 2021Article
- Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling.Frontiers in cell and developmental biology · 2021Review
- Emerging Role of Mucosal Vaccine in Preventing Infection with Avian Influenza A Viruses.Viruses · 2020Review
- Leishmania donovani infection induce differential miRNA expression in CD4+ T cells.Scientific reports · 2020Article
- Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain:Journal of immunology research · 2020Article
- MiR-let-7d-3p regulates IL-17 expression through targeting AKT1/mTOR signaling in CD4In vitro cellular & developmental biology. Animal · 2020Article
- The dynamics of the inflammatory response during BBN-induced bladder carcinogenesis in mice.Journal of translational medicine · 2019Article
- A multi-method and structure-based in silico vaccine designing againstBioImpacts : BI · 2019Article
- Type 2 immunity in tissue repair and fibrosis.Nature reviews. Immunology · 2018Review
- Adaptive Immune Responses Contribute to Post-ischemic Cardiac Remodeling.Frontiers in cardiovascular medicine · 2018Review
- Review
- T helper 2 and T follicular helper cells: Regulation and function of interleukin-4.Cytokine & growth factor reviews · 2016Review
- T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Tailored immune responses: novel effector helper T cell subsets in protective immunity.PLoS pathogens · 2014Review
- IL-4 and IL-13 differentially regulate TLR-induced eosinophil-basophil differentiation of cord blood CD34+ progenitor cells.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Over the past 10 years we have made great strides in our understanding of T helper cell differentiation, expansion and effector functions. Within the context of T helper type 2 (Th2) cell development, novel innate-like cells with the capacity to secrete large amounts of interleukin-5 (IL-5), IL-13 and IL-9 as well as IL-4-producing and antigen-processing basophils have (re)-emerged onto the type 2 scene. To what extent these new players influence αβ+ CD4+ Th2 cell differentiation is discussed throughout this appraisal of the current literature. We highlight the unique features of Th2 cell development, highlighting the three necessary signals, T-cell receptor ligation, co-stimulation and cytokine receptor ligation. Finally, putting these into context, microbial and allergenic properties that trigger Th2 cell differentiation and how these influence Th2 effector function are discussed and questioned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.