ArticleAdvances in nutrition (Bethesda, Md.)2010
Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis.
Article in Advances in nutrition (Bethesda, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Comparing the types of haemochromatosis- from genetics to clinics.European journal of human genetics : EJHG · 2026Review
- Mechanism of AGEs-RAGE axis inhibition of ferroptosis in type 2 diabetic colon cancer by regulatory CEACAM1.Scientific reports · 2026Article
- Insights into Iron Metabolism Parameters in Ischemic Stroke: A Single-Center Prospective Cohort Study.International journal of molecular sciences · 2024Article
- Dietary contribution of iron from limestone and dicalcium phosphate for broiler chickens.Poultry science · 2024Article
- Iron Deposition in Brain: Does Aging Matter?International journal of molecular sciences · 2022Review
- Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis.Cancers · 2021Article
- Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders.International journal of molecular sciences · 2021Review
- Urine hemojuvelin in cats with naturally occurring kidney disease.Journal of veterinary internal medicine · 2020Article
- Inflammation Mediated Hepcidin-Ferroportin Pathway and Its Therapeutic Window in Breast Cancer.Breast cancer (Dove Medical Press) · 2020Review
- Serum iron concentration as a marker of inflammation in young cows that underwent dehorning operation.The Journal of veterinary medical science · 2019Article
- Iron deficiency as energetic insult to skeletal muscle in chronic diseases.Journal of cachexia, sarcopenia and muscle · 2018Review
- Hepcidin and ferroportin expression in breast cancer tissue and serum and their relationship with anemia.Current oncology (Toronto, Ont.) · 2016Article
- 3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach.Pharmaceuticals (Basel, Switzerland) · 2016Article
- Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels.Genes & nutrition · 2016Article
- Resistance to Recombinant Human Erythropoietin Therapy in a Rat Model of Chronic Kidney Disease Associated Anemia.International journal of molecular sciences · 2015Article
- Sox2 function as a negative regulator to control HAMP expression.Biological research · 2015Article
- Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control.Protein & cell · 2014Review
- METABOLISM OF IRON STORES.Nagoya journal of medical science · 2014Review
- Hepcidin and sports anemia.Cell & bioscience · 2014Review
- Iron as the key modulator of hepcidin expression in erythroid antibody-mediated hypoplasia.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Systemic iron homeostasis is maintained by the coordinate regulation of iron absorption in the duodenum, iron recycling of senescent erythrocytes in macrophages, and mobilization of storage iron in the liver. These processes are controlled by hepcidin, a key iron regulatory hormone. Hepcidin is a 25-amino acid peptide secreted predominantly from hepatocytes. It downregulates ferroportin, the only known iron exporter, and therefore inhibits iron efflux from duodenal enterocytes, macrophages, and hepatocytes into the circulation. Hepcidin expression is regulated positively by body iron load. Although the underlying mechanism of iron-regulated hepcidin expression has not been fully elucidated, several proteins have been identified that participate in this process. Among them, hemojuvelin (HJV) plays a particularly important role. HJV undergoes complicated post-translational processing in an iron-dependent manner, and it interacts with multiple proteins that are essential for iron homeostasis. In this review, I focus on the recent findings that elucidate the role of HJV and its interacting partners in the modulation of hepatic hepcidin expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.