Evidence map›Paper›PMID 22043447›Full record

ArticleAdvances in nutrition (Bethesda, Md.)2010

Epigenetics: A New Bridge between Nutrition and Health.

Sang-Woon Choi, Simonetta Friso

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in nutrition (Bethesda, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 6 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 6 syntheses or guidelines pooled it, 578 citations in OpenAlex.

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  18. Crosstalk BetweenCancers · 2026
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sang-Woon ChoiVitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111.
Simonetta Friso
Tufts University · USUniversity of Verona · IT

Funding

Effects of aging and folate on colonic carcinogenesisR01AG025834 · NIA · TUFTS UNIVERSITY BOSTON · PI CHOI, SANG WOON · 2007 to 2011
$1.3M
Epigenetic effects of chronic alcohol consumption on colonic mucosaR21AA016681 · NIAAA · TUFTS UNIVERSITY BOSTON · PI CHOI, SANG WOON · 2006 to 2007
$370k
NIAAA NIH HHS R21 AA016681NIA NIH HHS R01 AG025834
6 · The paper itself

Abstract

Nutrients can reverse or change epigenetic phenomena such as DNA methylation and histone modifications, thereby modifying the expression of critical genes associated with physiologic and pathologic processes, including embryonic development, aging, and carcinogenesis. It appears that nutrients and bioactive food components can influence epigenetic phenomena either by directly inhibiting enzymes that catalyze DNA methylation or histone modifications, or by altering the availability of substrates necessary for those enzymatic reactions. In this regard, nutritional epigenetics has been viewed as an attractive tool to prevent pediatric developmental diseases and cancer as well as to delay aging-associated processes. In recent years, epigenetics has become an emerging issue in a broad range of diseases such as type 2 diabetes mellitus, obesity, inflammation, and neurocognitive disorders. Although the possibility of developing a treatment or discovering preventative measures of these diseases is exciting, current knowledge in nutritional epigenetics is limited, and further studies are needed to expand the available resources and better understand the use of nutrients or bioactive food components for maintaining our health and preventing diseases through modifiable epigenetic mechanisms.

Identifiers

PMID22043447
PMCPMC3042783
OpenAlexW2129763461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.