ArticleTherapeutic advances in gastroenterology2011
Management of colonic diverticular disease with poorly absorbed antibiotics and other therapies.
Article in Therapeutic advances in gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- The Trends of Complicated Acute Colonic Diverticulitis-A Systematic Review of the National Administrative Databases.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Mesalazine for People with Diverticular Disease: A Systematic Review of Randomized Controlled Trials.Canadian journal of gastroenterology & hepatology · 2018Pooled it
- Supplementation with Lactobacillus reuteri ATCC PTA 4659 in patients affected by acute uncomplicated diverticulitis: a randomized double-blind placebo controlled trial.International journal of colorectal disease · 2019Trial
- Anemia and Its Connections to Inflammation in Older Adults: A Review.Journal of clinical medicine · 2024Review
- Pathophysiology and Therapeutic Strategies for Symptomatic Uncomplicated Diverticular Disease of the Colon.Digestive diseases and sciences · 2016Review
- Diverticula and Diverticulitis: Time for a Reappraisal.Gastroenterology & hepatology · 2015Article
- Diverticular disease: changing epidemiology and management.Drugs & aging · 2015Review
- Perforated diverticulitis sigmoidei after laparoscopic cholecystectomy.Journal of surgical case reports · 2015Article
- Development and validation of a disease-targeted quality of life instrument for chronic diverticular disease: the DV-QOL.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Italian consensus conference for colonic diverticulosis and diverticular disease.United European gastroenterology journal · 2014Article
- Secondary peritonitis - evaluation of 204 cases and literature review.Journal of medicine and life · 2014Review
- New strategies for the management of diverticular disease: insights for the clinician.Therapeutic advances in gastroenterology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonic diverticular disease is common in Western countries and its prevalence increases with age. The large majority of patients (80-85%) will remain entirely asymptomatic throughout their life. In symptomatic cases, most patients will have diverticulosis without inflammation while the remainder will have diverticulitis with or without complications. About 1-2% will require hospitalization and 0.5% will require surgery. Factors predicting the development of symptoms remain to be identified. However, it is generally recognized that diverticular disease is probably related to complex interactions between colon structure, intestinal motility, diet, and genetic features. Epidemiologic studies have demonstrated an association between diverticulosis and diets that are low in fiber and high in refined carbohydrates. Although the causes of symptom development are still unclear, it is thought that previous episodes of intestinal inflammation may play a role. Changes in intestinal microflora could be one of the putative mechanisms responsible for low-grade inflammation. In patients with uncomplicated diverticulosis, a diet abundant in fruit and vegetables is recommended. The current therapeutic approaches in preventing recurrence of symptoms are based on nonabsorbable antibiotics, mesalazine, and/or probiotics. Cyclic rifaximin administration seems to be an adequate approach to relieving symptoms and preventing acute diverticulitis in patients with symptomatic diverticulosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.