Trial reportSleep2011
The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population.
Trial report in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Changes in Pediatric Obstructive Sleep Apnea
OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.
- Tonsillectomy or adenotonsillectomy versus non-surgical management for obstructive sleep-disordered breathing in children.The Cochrane database of systematic reviews · 2015Pooled it
- Supine position-related obstructive sleep apnea in children: insights from the Childhood Adenotonsillectomy Trial.Sleep & breathing = Schlaf & Atmung · 2025Trial
- Utilisation of machine learning to predict surgical candidates for the treatment of childhood upper airway obstruction.Sleep & breathing = Schlaf & Atmung · 2022Trial
- Trial
- Sleep apnea diagnosis in children using software-generated apnea-hypopnea index (AHI) derived from data recorded with a single photoplethysmogram sensor (PPG) : Results from the Childhood Adenotonsillectomy Study (CHAT) based on cardiopulmonary coupling analysis.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Objective sleep quality and metabolic risk in healthy weight children results from the randomized Childhood Adenotonsillectomy Trial (CHAT).Sleep & breathing = Schlaf & Atmung · 2019Trial
- Trial
- Effect of adenotonsillectomy for childhood obstructive sleep apnea on nocturnal heart rate patterns.Sleep · 2018Trial
- Effects of Adenotonsillectomy on Parent-Reported Behavior in Children With Obstructive Sleep Apnea.Sleep · 2017Trial
- Effect of Adenotonsillectomy on Parent-Reported Sleepiness in Children with Obstructive Sleep Apnea.Sleep · 2016Trial
- Montelukast for Children with Obstructive Sleep Apnea: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.Annals of the American Thoracic Society · 2016Trial
- Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea.Pediatrics · 2016Trial
- Trial
- Trial
- Trial
- Utility of symptoms to predict treatment outcomes in obstructive sleep apnea syndrome.Pediatrics · 2015Trial
- The use of clinical parameters to predict obstructive sleep apnea syndrome severity in children: the Childhood Adenotonsillectomy (CHAT) study randomized clinical trial.JAMA otolaryngology-- head & neck surgery · 2015Trial
- Quality of life and obstructive sleep apnea symptoms after pediatric adenotonsillectomy.Pediatrics · 2015Trial
- Growth after adenotonsillectomy for obstructive sleep apnea: an RCT.Pediatrics · 2014Trial
- Trial
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
Abstract
Each year, over 500,000 adenotonsillectomies (AT), mostly for the treatment of pediatric obstructive sleep apnea (OSA) are performed in the US in children under 15 years of age. No definitive study, however, has been yet conducted that has rigorously evaluated the effectiveness of AT for not only improving sleep disordered breathing, but also for improving clinically relevant outcomes, such as neurocognitive function, behavior, and quality of life. The Childhood Adenotonsillectomy Trial (CHAT) was designed to assess neuropsychological and health outcomes in children randomized to receive early AT (eAT) as compared to Watchful Waiting with Supportive Care (WWSC). Important secondary goals of the study are to evaluate outcomes in subgroups defined by obesity and race. This paper addresses key elements in the design and implementation of a controlled trial for a widely used "standard practice" surgical intervention in a pediatric population, that include establishment of standardized data collection procedures across sites for a wide variety of data types, establishment of equipoise, and approaches for minimizing unblinding of selected key personnel. The study framework that was established should provide a useful template for other pediatric controlled studies or other studies that evaluate surgical interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.