ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2011
Expression of dentin sialophosphoprotein in non-mineralized tissues.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- Intracranial calcification in Fam20c-deficient mice recapitulates human Raine syndrome.Neuroscience letters · 2023Article
- The effect of BMP4, FGF8 and WNT3a on mouse iPS cells differentiating to odontoblast-like cells.Medical molecular morphology · 2022Article
- Effects ofGlobal medical genetics · 2021Review
- Identification of Novel Candidate Genes and Variants for Hearing Loss and Temporal Bone Anomalies.Genes · 2021Article
- Dentin Sialophosphoprotein Deletion Leads to Femoral Head Cartilage Attenuation and Subchondral Bone Ill-mineralization.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Haploinsufficiency ofFrontiers in physiology · 2020Article
- The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein.International journal of oral science · 2018Review
- Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation.Connective tissue research · 2018Article
- Transgenic expression of dentin phosphoprotein inhibits skeletal development.European journal of histochemistry : EJH · 2016Article
- Recombinant Amelogenin Protein Induces Apical Closure and Pulp Regeneration in Open-apex, Nonvital Permanent Canine Teeth.Journal of endodontics · 2016Article
- Dentin Matrix Proteins in Bone Tissue Engineering.Advances in experimental medicine and biology · 2015Review
- Overexpressing the NHJournal of oral biosciences · 2014Article
- Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice.European journal of oral sciences · 2013Article
- Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells.The Journal of biological chemistry · 2013Article
- Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.European journal of oral sciences · 2013Article
- Loss of dentin sialophosphoprotein leads to periodontal diseases in mice.Journal of periodontal research · 2013Article
- The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.The Journal of biological chemistry · 2013Article
- Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.The Journal of biological chemistry · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Dentin sialophosphoprotein (DSPP) and its cleaved products, dentin phosphoprotein (DPP) and dentin sialoprotein (DSP), play important roles in biomineralization. Believed to be tooth specific, the authors' group revealed its expression in bone, and more recently, they and other groups also showed its expression in a few types of soft tissues. In this study, the authors systematically examined the expression of DSPP in a variety of non-mineralized tissues using reverse-transcription polymerase chain reaction (RT-PCR), real-time PCR, Western immunoblotting, and immunohistochemistry analyses in wild-type mice as well as β-galactosidase assays in the Dspp lacZ knock-in mice. These approaches showed the presence of DSPP in the salivary glands, cartilage, liver, kidney, and brain and its absence in the heart and spleen. Real-time PCR showed that the expression levels of DSPP mRNA in salivary glands, cartilage, liver, and kidney were higher than in the bone. Interestingly, DSPP was observed in the pericytes of blood vessels in the dental pulp, which are believed to be able to differentiate into odontoblasts. On the basis of these observations, the authors conclude that DSPP and/or its cleaved products may fulfill important functions in certain non-mineralized tissues in addition to its role in biomineralization.
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