ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011
Brain-immune interactions and the neural basis of disease-avoidant ingestive behaviour.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Retrieval of conditioned immune response in male mice is mediated by an anterior-posterior insula circuit.Nature neuroscience · 2025Article
- Neuronal basis and diverse mechanisms of pathogen avoidance inFrontiers in immunology · 2024Review
- Behavioral and Neuropathological Changes AfterFrontiers in cellular and infection microbiology · 2022Article
- Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States.Frontiers in immunology · 2021Review
- Neural control of behavioral and molecular defenses in C. elegans.Current opinion in neurobiology · 2020Review
- Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation.Journal of neuroinflammation · 2019Article
- The role of social cognition in parasite and pathogen avoidance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Feeding decisions under contamination risk in bonobos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Interoception and Inflammation in Psychiatric Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- Reciprocal Interactions Between Gut Microbiota and Host Social Behavior.Frontiers in integrative neuroscience · 2018Review
- Interferon-α acutely impairs whole-brain functional connectivity network architecture - A preliminary study.Brain, behavior, and immunity · 2016Article
- The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease.Trends in immunology · 2015Review
- Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation.Behavioural neurology · 2015Review
- TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.Journal of molecular medicine (Berlin, Germany) · 2014Review
- Aberrant disgust responses and immune reactivity in cocaine-dependent men.Biological psychiatry · 2014Article
- Learned immunosuppression: extinction, renewal, and the challenge of reconsolidation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- Proactive strategies to avoid infectious disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuro-immune interactions are widely manifested in animal physiology. Since immunity competes for energy with other physiological functions, it is subject to a circadian trade-off between other energy-demanding processes, such as neural activity, locomotion and thermoregulation. When immunity is challenged, this trade-off is tilted to an adaptive energy protecting and reallocation strategy that is identified as 'sickness behaviour'. We review diverse disease-avoidant behaviours in the context of ingestion, indicating that several adaptive advantages have been acquired by animals (including humans) during phylogenetic evolution and by ontogenetic experiences: (i) preventing waste of energy by reducing appetite and consequently foraging/hunting (illness anorexia), (ii) avoiding unnecessary danger by promoting safe environments (preventing disease encounter by olfactory cues and illness potentiation neophobia), (iii) help fighting against pathogenic threats (hyperthermia/somnolence), and (iv) by associative learning evading specific foods or environments signalling danger (conditioned taste avoidance/aversion) and/or at the same time preparing the body to counteract by anticipatory immune responses (conditioning immunomodulation). The neurobiology behind disease-avoidant ingestive behaviours is reviewed with special emphasis on the body energy balance (intake versus expenditure) and an evolutionary psychology perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.