ArticleCirculation. Cardiovascular genetics2011
Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.
Article in Circulation. Cardiovascular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies.Frontiers in cardiovascular medicine · 2025Pooled it
- Genetic variants at chromosome 9p21 and risk of first versus subsequent coronary heart disease events: a systematic review and meta-analysis.Journal of the American College of Cardiology · 2014Pooled it
- Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: the PAGE study.PloS one · 2014Pooled it
- Pooled it
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- Associations between PHACTR1 gene polymorphisms and pulse pressure in Chinese Han population.Bioscience reports · 2020Article
- Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.American journal of human genetics · 2020Article
- Genes associated with inflammation may serve as biomarkers for the diagnosis of coronary artery disease and ischaemic stroke.Lipids in health and disease · 2020Article
- The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort.Scientific reports · 2019Article
- Clinical application of chromosome 9p21.3 genotyping in patients with coronary artery disease.Experimental and therapeutic medicine · 2019Article
- Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke.BMC cardiovascular disorders · 2019Article
- Genetic Epidemiologic Analysis of Hypertensive Retinopathy in an Underrepresented and Rare Federally Recognized Native American Population of the Intermountain West.Journal of community medicine & public health · 2019Article
- How Genomics Is Personalizing the Management of Dyslipidemia and Cardiovascular Disease Prevention.Current cardiology reports · 2018Review
- Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead.Current atherosclerosis reports · 2018Review
Corrections and comments
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Authors and funding
24 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGenome-wide association studies identified several single nucleotide polymorphisms (SNP) associated with prevalent coronary heart disease (CHD), but less is known of associations with incident CHD. The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts. METHODS AND
resultsThe analyses included incident coronary events over an average 9.1 to 15.7 follow-up person-years in up to 26 617 white individuals (6626 events), 8018 black individuals (914 events), 1903 Hispanic individuals (113 events), 3669 American Indian individuals (595 events), and 885 Asian/Pacific Islander individuals (66 events). We used Cox proportional hazards models (with additive mode of inheritance) adjusted for age, sex, and ancestry (as needed). Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)). The 9p21 region showed significant between-study heterogeneity, with larger effects in individuals age 55 years or younger and in women. Inclusion of coronary revascularization procedures among the incident CHD events introduced heterogeneity. The SNPs were not associated with CHD in black participants, and associations varied in other US minorities.
conclusionsProspective analyses of white participants replicated several reported cross-sectional CHD-SNP associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.