ArticleProceedings of the National Academy of Sciences of the United States of America2011
Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- mTOR signaling contributes to system-driven rhythmic gene expression in mouse liver.Science advances · 2026Article
- Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake.Science (New York, N.Y.) · 2024Article
- Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins.Aging and disease · 2022Article
- Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.Journal of biological rhythms · 2022Article
- Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis.Science advances · 2022Article
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Model learning to identify systemic regulators of the peripheral circadian clock.Bioinformatics (Oxford, England) · 2021Article
- How the Intensity of Night Shift Work Affects Breast Cancer Risk.International journal of environmental research and public health · 2021Article
- Revealing the hidden reality of the mammalian 12-h ultradian rhythms.Cellular and molecular life sciences : CMLS · 2021Review
- Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines.International journal of molecular sciences · 2021Article
- Systems Level Understanding of Circadian Integration with Cell Physiology.Journal of molecular biology · 2020Review
- 12-h clock regulation of genetic information flow by XBP1s.PLoS biology · 2020Article
- Boolean function network analysis of time course liver transcriptome data to reveal novel circadian transcriptional regulators in mammals.Journal of the Chinese Medical Association : JCMA · 2019Article
- Daily variation of gene expression in diverse rat tissues.PloS one · 2018Article
- A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.Nature cell biology · 2018Article
- Circadian mRNA expression: insights from modeling and transcriptomics.Cellular and molecular life sciences : CMLS · 2016Review
- Intrinsic muscle clock is necessary for musculoskeletal health.The Journal of physiology · 2015Article
- Circadian redox and metabolic oscillations in mammalian systems.Antioxidants & redox signaling · 2014Review
- Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models.PLoS genetics · 2014Article
- Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The circadian clock generates daily rhythms in mammalian liver processes, such as glucose and lipid homeostasis, xenobiotic metabolism, and regeneration. The mechanisms governing these rhythms are not well understood, particularly the distinct contributions of the cell-autonomous clock and central pacemaker to rhythmic liver physiology. Through microarray expression profiling in Met murine hepatocytes (MMH)-D3, we identified over 1,000 transcripts that exhibit circadian oscillations, demonstrating that the cell-autonomous clock can drive many rhythms, and that MMH-D3 is a valid circadian model system. The genes represented by these circadian transcripts displayed both cophasic and antiphasic organization within a protein-protein interaction network, suggesting the existence of competition for binding sites or partners by genes of disparate transcriptional phases. Multiple pathways displayed enrichment in MMH-D3 circadian transcripts, including the polyamine synthesis module of the glutathione metabolic pathway. The polyamine synthesis module, which is highly associated with cell proliferation and whose products are required for initiation of liver regeneration, includes enzymes whose transcripts exhibit circadian oscillations, such as ornithine decarboxylase and spermidine synthase. Metabolic profiling revealed that the enzymatic product of spermidine synthase, spermidine, cycles as well. Thus, the cell-autonomous hepatocyte clock can drive a significant amount of transcriptional rhythms and orchestrate physiologically relevant modules such as polyamine synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.