ArticleGenetics2012
Altitudinal variation at duplicated β-globin genes in deer mice: effects of selection, recombination, and gene conversion.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Hemoglobin-Gene Cluster Deletions in Antarctic White-Blooded Icefishes Facilitated by Transposable Elements.Genome biology and evolution · 2025Article
- Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia.Molecular aspects of medicine · 2022Review
- Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.The Journal of experimental biology · 2022Article
- A New Homotetramer Hemoglobin in the Pulmonary Surfactant of Plateau Zokors (Frontiers in genetics · 2022Article
- Exome sequencing of deer mice on two California Channel Islands identifies potential adaptation to strongly contrasting ecological conditions.Ecology and evolution · 2021Article
- Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.Molecular biology and evolution · 2021Article
- High-Altitude Adaptation: Mechanistic Insights from Integrated Genomics and Physiology.Molecular biology and evolution · 2021Review
- The adaptive benefit of evolved increases in hemoglobin-OBMC biology · 2021Article
- Article
- Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude.The Journal of experimental biology · 2020Article
- Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice.PLoS genetics · 2019Article
- Regulation of catecholamine release from the adrenal medulla is altered in deer mice (American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Journal of mammalogy · 2019Article
- UNVEILing connections between genotype, phenotype, and fitness in natural populations.Molecular ecology · 2019Article
- Article
- Gene expression is implicated in the ability of pikas to occupy Himalayan elevational gradient.PloS one · 2018Article
- Population structure and local selection yield high genomic variation in Mimulus guttatus.Molecular ecology · 2017Article
- Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2016Article
- Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.Advances in experimental medicine and biology · 2016Review
- Adaptive Modifications of Muscle Phenotype in High-Altitude Deer Mice Are Associated with Evolved Changes in Gene Regulation.Molecular biology and evolution · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Spatially varying selection on a given polymorphism is expected to produce a localized peak in the between-population component of nucleotide diversity, and theory suggests that the chromosomal extent of elevated differentiation may be enhanced in cases where tandemly linked genes contribute to fitness variation. An intriguing example is provided by the tandemly duplicated β-globin genes of deer mice (Peromyscus maniculatus), which contribute to adaptive differentiation in blood-oxygen affinity between high- and low-altitude populations. Remarkably, the two β-globin genes segregate the same pair of functionally distinct alleles due to a history of interparalog gene conversion and alleles of the same functional type are in perfect coupling-phase linkage disequilibrium (LD). Here we report a multilocus analysis of nucleotide polymorphism and LD in highland and lowland mice with different genetic backgrounds at the β-globin genes. The analysis of haplotype structure revealed a paradoxical pattern whereby perfect LD between the two β-globin paralogs (which are separated by 16.2 kb) is maintained in spite of the fact that LD within both paralogs decays to background levels over physical distances of less than 1 kb. The survey of nucleotide polymorphism revealed that elevated levels of altitudinal differentiation at each of the β-globin genes drop away quite rapidly in the external flanking regions (upstream of the 5' paralog and downstream of the 3' paralog), but the level of differentiation remains unexpectedly high across the intergenic region. Observed patterns of diversity and haplotype structure are difficult to reconcile with expectations of a two-locus selection model with multiplicative fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.