Evidence map›Paper›PMID 22042093›Full record

ArticleJournal of molecular histology2012

Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in postnatal developing mouse teeth.

C Hou, Z X Liu, K L Tang, M G Wang, J Sun, J Wang, S Li

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Frontiers in cell and developmental biology · 2022
    Article
  6. Article
  7. Article
  8. MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

C HouShandong Provincial Key Laboratory of Oral Biomedicine, Department of Periodontology, School of Stomatology Shandong University, 44-1# West Wenhua Road, Jinan, 250012, Shandong, People's Republic of China.
Z X Liu
K L Tang
M G Wang
J Sun
J Wang
S Li
Shandong University · CNJinan Stomatological Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been implicated noncollagenous proteins act as important regulators during odontogenesis. To test the hypothesis that the roles of Dspp, Mepe, Versican and Mimecan in the regulation of odontogenesis may be complementary, comparative investigations on the localization of four proteins were performed by immunohistochemical staining using mouse first molar at different developmental stages as a model. In postnatal 1- day-old mice, all the proteins, excluding Mepe, showed co-expression in young odontoblasts. At postnatal 3, strong immunoreactions for all proteins were detected in odontoblasts. Interestingly, Mepe was present within both cytoplasm and nucleus in odontoblasts. In mice older than 5 days, the expression of Dspp, Mimecan and Versican accumulated in subodontoblastic layer of the coronal pulp at high levels while the co-expression of Mepe and Mimecan significantly existed in predentin. The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis.

Indexed as

AnimalsDentin SialophosphoproteinExtracellular Matrix ProteinsGene Expression ProfilingGene Expression Regulation, DevelopmentalGlycoproteinsImmunohistochemistryIntercellular Signaling Peptides and ProteinsMiceMice, Inbred BALB COdontogenesisPhosphoproteinsSialoglycoproteinsToothVersicansDentin SialophosphoproteinExtracellular Matrix ProteinsGlycoproteinsIntercellular Signaling Peptides and ProteinsMepe protein, mouseOgn protein, mousePhosphoproteinsSialoglycoproteinsVcan protein, mouseVersicans

Identifiers

PMID22042093
OpenAlexW2015781644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.