ReviewJournal of gastroenterology2012
Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry.
Review in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Metabolomics evaluation of serum markers for cachexia and their intra-day variation in patients with advanced pancreatic cancer.PloS one · 2014Trial
- Serum β-hydroxybutyrate as a diagnostic biomarker distinguishing acute calcium pyrophosphate crystal arthritis from rheumatoid arthritis.Clinical rheumatology · 2026Article
- Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats.Scientific reports · 2025Article
- MSIMG: A Density-Aware Multi-Channel Image Representation Method for Mass Spectrometry.Sensors (Basel, Switzerland) · 2025Article
- From Biomarker Discovery to Clinical Applications of Metabolomics in Glioblastoma.Metabolites · 2025Review
- Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma.Molecular cancer · 2024Review
- Exploration of Metabolite Biomarkers to Predict the Efficacy of Dupilumab Treatment for Atopic Dermatitis.Disease markers · 2023Article
- Metabolomics Research in Periodontal Disease by Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Review
- Metabolomics Approaches for the Comprehensive Evaluation of Fermented Foods: A Review.Foods (Basel, Switzerland) · 2021Review
- Article
- The potential of metabolic and lipid profiling in inflammatory bowel diseases: A pilot study.Bosnian journal of basic medical sciences · 2020Article
- Differences in plasma metabolites related to Alzheimer's disease,Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Serum metabolites as predictive molecular markers of ovarian response to controlled stimulation: a pilot study.JBRA assisted reproduction · 2019Article
- Application of GC/MS-Based Metabonomic Profiling in Studying the Therapeutic Effects ofMolecules (Basel, Switzerland) · 2019Article
- Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine.Journal of clinical biochemistry and nutrition · 2019Article
- Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer.Oncology letters · 2019Article
- Metabolomics: From liver chiromancy to personalized precision medicine in advanced chronic liver disease.World journal of hepatology · 2018Review
- Metabolomics for the early detection of cisplatin-induced nephrotoxicity.Toxicology research · 2017Article
- Serum metabolomics analysis for early detection of colorectal cancer.Journal of gastroenterology · 2017Article
- Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.Arthritis research & therapy · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, metabolome analysis has been increasingly applied to biomarker detection and disease diagnosis in medical studies. Metabolome analysis is a strategy for studying the characteristics and interactions of low molecular weight metabolites under a specific set of conditions and is performed using mass spectrometry and nuclear magnetic resonance spectroscopy. There is a strong possibility that changes in metabolite levels reflect the functional status of a cell because alterations in their levels occur downstream of DNA, RNA, and protein. Therefore, the metabolite profile of a cell is more likely to represent the current status of a cell than DNA, RNA, or protein. Thus, owing to the rapid development of mass spectrometry analytical techniques metabolome analysis is becoming an important experimental method in life sciences including the medical field. Here, we describe metabolome analysis using liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry (GC-MS), capillary electrophoresis-mass spectrometry, and matrix assisted laser desorption ionization-mass spectrometry. Then, the findings of studies about GC-MS-based metabolome analysis of gastroenterological diseases are summarized, and our research results are also introduced. Finally, we discuss the realization of disease diagnosis by metabolome analysis. The development of metabolome analysis using mass spectrometry will aid the discovery of novel biomarkers, hopefully leading to the early detection of various diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.