Trial reportInternal medicine (Tokyo, Japan)2011
Is liver cirrhosis a risk factor for osteonecrosis of the femoral head in adults? A population-based 3-year follow-up study.
Trial report in Internal medicine (Tokyo, Japan), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Common musculoskeletal disorders in chronic liver disease patients.Joint diseases and related surgery · 2021Article
- Evaluating the association between avascular necrosis of femoral head and oral corticosteroids use in Taiwan.Medicine · 2020Observational
- Bone Diseases in Patients with Chronic Liver Disease.International journal of molecular sciences · 2019Review
- Impact of Cirrhosis on Pneumonia-Related Outcomes in Hospitalized Older Veterans.The American journal of the medical sciences · 2019Article
- Cirrhosis-related musculoskeletal disease: radiological review.The British journal of radiology · 2016Review
- Cirrhosis is a risk factor for total hip arthroplasty for avascular necrosis.Acta orthopaedica · 2016Article
- Increased occurrence of native septic arthritis in adult cirrhotic patients: a population-based three-year follow-up study in Taiwan.Przeglad gastroenterologiczny · 2014Article
- High mortality of pneumonia in cirrhotic patients with ascites.BMC gastroenterology · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between osteonecrosis of the femoral head (OFH) and liver cirrhosis is controversial. The aim of this study was to determine whether liver cirrhosis is associated with the occurrence of OFH.
methodsWe used the National Health Insurance Database, derived from the Taiwan National Health Insurance program. The study cohort comprised 40,769 adult patients with liver cirrhosis. The comparison cohort consisted of 40,769 randomly selected age- and sex-matched subjects.
resultsDuring the 3-year follow-up period, there were 321 (0.8%) cirrhotic patients with OFH, and 126 (0.3%) non-cirrhotic patients with OFH (p<0.001). Cox's regression analysis, adjusted by the patients' age, sex, and other confounding factors, showed that the cirrhotic patients had a higher risk for occurrence of OFH than non-cirrhotic patients during the 3-year period (hazard ratio=2.38, p<0.001). In this 3-year study, the incidence density of cirrhotic patients hospitalized for OFH was 3 episodes/1,000 person-year.
conclusionWe conclude that cirrhotic patients have a higher risk for occurrence of OFH than non-cirrhotic patients.
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