Trial reportDrug and alcohol dependence2012
A preliminary study of the neural effects of behavioral therapy for substance use disorders.
Trial report in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03842670 (Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological), which is not on this map. Cited by 70 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurocognitive and Neurobehavioral Mechanisms of Change Following Psychological
Who cites it
70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Psychotherapy and inhibitory control: Insights from fMRI research.Psychiatry and clinical neurosciences · 2026Pooled it
- Not All Stroop-Type Tasks Are Alike: Assessing the Impact of Stimulus Material, Task Design, and Cognitive Demand via Meta-analyses Across Neuroimaging Studies.Neuropsychology review · 2025Pooled it
- Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies.Drug and alcohol dependence · 2022Pooled it
- Neural Effects of Cognitive Behavioral Therapy in Psychiatric Disorders: A Systematic Review and Activation Likelihood Estimation Meta-Analysis.Frontiers in psychology · 2022Pooled it
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge-Eating Disorder.The International journal of eating disorders · 2024Trial
- Longitudinal changes in network engagement during cognitive control in cocaine use disorder.Drug and alcohol dependence · 2021Trial
- Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula-bed nucleus of the stria terminalis resting-state functional connectivity.Alcoholism, clinical and experimental research · 2021Trial
- Functional neural changes following behavioral therapies and disulfiram for cocaine dependence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017Trial
- Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings.Drug and alcohol dependence · 2016Trial
- A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.Journal of psychopharmacology (Oxford, England) · 2015Trial
- Cannabis abstinence during treatment and one-year follow-up: relationship to neural activity in men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Neurobiological considerations in understanding behavioral treatments for pathological gambling.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2013Trial
- Bi-objective location-allocation model of interventions in high drug consumption areas incorporating X topic modeling.Health care management science · 2026Article
- Behavioral therapies targeting reward mechanisms in substance use disorders.Pharmacology, biochemistry, and behavior · 2024Review
- Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine.bioRxiv : the preprint server for biology · 2024Article
- Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment.Drug and alcohol dependence reports · 2024Article
- Neural correlates of drinking reduction during a clinical trial of cognitive behavioral therapy for alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research.Current addiction reports · 2024Review
- Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.Dialogues in clinical neuroscience · 2023Review
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe mechanisms by which behavioral therapies for substance use disorders (SUDs) exert their effects and the components of treatment that contribute most to substance use outcome remain unclear. Disruptions to aspects of impulse control and attention have been hypothesized to contribute to the development and maintenance of addiction; moreover, alterations in these processes may underlie responses to treatment.
methodsIndividuals participating in a randomized clinical trial evaluating computer-assisted cognitive behavioral therapy (CBT) for substance abuse participated in fMRI Stroop before and after treatment. A non-substance-using comparison group performed the same task under test-retest conditions.
resultsThe patient group demonstrated decreased Stroop-related BOLD signal in regions including the anterior cingulate, inferior frontal gyrus and midbrain at post-treatment relative to pre-treatment, and displayed a greater decrease in the subthalamic nucleus and surrounding regions compared to healthy controls following test-retest.
conclusionsBehavioral therapies may be associated with reduction in substance use and effects on neural systems involved in cognitive control, impulsivity, motivation and attention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.