ArticleThe Journal of physiology2011
Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) KScience advances · 2024Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Spatial information transfer in hippocampal place cells depends on trial-to-trial variability, symmetry of place-field firing, and biophysical heterogeneities.Neural networks : the official journal of the International Neural Network Society · 2021Article
- Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts.Nature communications · 2021Article
- Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Degeneracy in the emergence of spike-triggered average of hippocampal pyramidal neurons.Scientific reports · 2020Article
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- Reduced axonal surface expression and phosphoinositide sensitivity in KNeurobiology of disease · 2018Article
- M current regulates firing mode and spike reliability in a collision-detecting neuron.Journal of neurophysiology · 2018Article
- Article
- Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.Neurobiology of aging · 2017Article
- Pharmacological modulation of the voltage-gated neuronal Kv7/KCNQ/M-channel alters the intrinsic excitability and synaptic responses of pyramidal neurons in rat prefrontal cortex slices.Acta pharmacologica Sinica · 2017Article
- Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study.Journal of computational neuroscience · 2017Article
- Modulation of Kv7 channels and excitability in the brain.Cellular and molecular life sciences : CMLS · 2017Review
- Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons.Neural plasticity · 2015Article
- M-type potassium conductance controls the emergence of neural phase codes: a combined experimental and neuron modelling study.Journal of the Royal Society, Interface · 2014Article
- Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The K(V)7/M-current is an important determinant of neuronal excitability and plays a critical role in modulating action potential firing. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. K(V)7/M-channels are highly concentrated in axons. However, the competing peptide, ankyrin G binding peptide (ABP) that disrupts axonal K(V)7/M-channel function, had little effect on somatic EPSP integration, suggesting that this effect was due to local somatic channels only. This interpretation was confirmed using computer simulations. Further, in accordance with the biophysical properties of the K(V)7/M-current, the effect of somatic K(V)7/M-channels on synaptic potential summation was dependent upon the neuronal membrane potential. Somatic K(V)7/M-channels thus affect EPSP-spike coupling by altering EPSP integration. Interestingly, disruption of axonal channels enhanced EPSP-spike coupling by lowering the action potential threshold. Hence, somatic and axonal K(V)7/M-channels influence EPSP-spike coupling via different mechanisms. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.