ArticleChinese medicine2011
Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice.
Article in Chinese medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease.BioMed research international · 2019Pooled it
- Balancing yield and stability: optimizing leaf pigment extraction to minimize chlorophyll degradation.Planta · 2025Article
- Lutein Encapsulated in PLGA-Phospholipid Nano-Carrier Effectively Mitigates Cytokines by Inhibiting Tumor Necrosis Factor TNF-α and Nuclear Factor NF-Journal of functional biomaterials · 2023Article
- Lutein Decreases Inflammation and Oxidative Stress and Prevents Iron Accumulation and Lipid Peroxidation at Glutamate-Induced Neurotoxicity.Antioxidants (Basel, Switzerland) · 2022Article
- Induction of lutein production inTurkish journal of chemistry · 2022Article
- Article
- Development of Lutein-Containing Eye Drops for the Treatment of Dry Eye Syndrome.Pharmaceutics · 2021Article
- Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids.Marine drugs · 2021Review
- Enzymatic Degradation ofMarine drugs · 2021Article
- Lutein Exerts Antioxidant and Anti-Inflammatory Effects and Influences Iron Utilization of BV-2 Microglia.Antioxidants (Basel, Switzerland) · 2021Article
- The effect of lutein and Urtica dioica extract on in vitro production of embryo and oxidative status in polycystic ovary syndrome in a model of mice.BMC complementary medicine and therapies · 2021Article
- Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats.Inflammation · 2018Article
- Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation.Archives of medical science : AMS · 2018Article
- Molecular Cloning and Characterization of Carotenoid Pathway Genes and Carotenoid Content in Ixeris dentata var. albiflora.Molecules (Basel, Switzerland) · 2017Article
- Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model.BMC ophthalmology · 2017Article
- Effects of Lutein on Hyperosmoticity-Induced Upregulation of IL-6 in Cultured Corneal Epithelial Cells and Its Relevant Signal Pathways.Journal of ophthalmology · 2016Article
- Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats.World journal of gastroenterology · 2015Article
- Lutein dietary supplementation attenuates streptozotocin-induced testicular damage and oxidative stress in diabetic rats.BMC complementary and alternative medicine · 2015Article
- Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?Journal of ophthalmology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLutein is an important eye-protective nutrient. This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice.
methodsLutein, suspended in drinking water at a final concentration of 12.5 and 25 mg/mL, was administered to mice at 0.1 mL/10 g body weight for five consecutive days. Control and model group received drinking water only. Uveitis was induced by injecting LPS (100 mg per mouse) into the footpad in the model and lutein groups on day 5 after the last drug administration. Eyes of the mice were collected 24 hours after the LPS injection for the detection of indicators using commercial kits and reverse transcription-polymerase chain reaction.
resultsLPS-induced uveitis was confirmed by significant pathological damage and increased the nitric oxide level in eye tissue of BALB/C mice 24 hours after the footpad injection. The elevated nitric oxide level was significantly reduced by oral administration of lutein (125 and 500 mg/kg/d for five days) before LPS injection. Moreover, lutein decreased the malondialdehyde content, increased the oxygen radical absorbance capacity level, glutathione, the vitamin C contents and total superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Lutein further increased expressions of copper-zinc SOD, manganese SOD and GPx mRNA. Conclusion The antioxidant properties of lutein contribute to the protection against LPS-induced uveitis, partially through the intervention of inflammation process.
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Registered trials
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