ReviewSeminars in cell & developmental biology2012
Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches.
Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety.Nature communications · 2026Article
- Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.Scientific reports · 2022Article
- Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.PLoS genetics · 2020Article
- Getting direction(s): The Eph/ephrin signaling system in cell positioning.Developmental biology · 2019Review
- TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration.Nature communications · 2018Article
- Regulation of Renal Differentiation by Trophic Factors.Frontiers in physiology · 2018Review
- Inverse Expression Levels of EphrinA3 and EphrinA5 Contribute to Dopaminergic Differentiation of Human SH-SY5Y Cells.Journal of molecular neuroscience : MN · 2016Article
- Article
- Understanding craniosynostosis as a growth disorder.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.Neural development · 2015Article
- Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.Developmental biology · 2015Article
- Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model".BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Article
- Axon guidance in the auditory system: multiple functions of Eph receptors.Neuroscience · 2014Review
- Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation.Biochimica et biophysica acta · 2013Review
- Molecular mechanisms underlying the effects of acupuncture on neuropathic pain.Neural regeneration research · 2013Article
- Eph receptor signaling and ephrins.Cold Spring Harbor perspectives in biology · 2013Review
- Analysis of EphA5 receptor in the developing rat brain: an in vivo study in congenital hypothyroidism model.European journal of pediatrics · 2013Article
- The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.Genes & development · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The Eph receptor tyrosine kinases and their ephrin partners compose a large and complex family of signaling molecules involved in a wide variety of processes in development, homeostasis, and disease. The complexity inherent to Eph/ephrin signaling derives from several characteristics of the family. First, the large size and functional redundancy/compensation by family members presents a challenge in defining their in vivo roles. Second, the capacity for bidirectional signaling doubles the potential complexity, since every member has the ability to act both as a ligand and a receptor. Third, Ephs and ephrins can utilize a wide array of signal transduction pathways with a tremendous diversity of cell biological effect. The daunting complexity of Eph/ephrin signaling has increasingly prompted investigators to resort to multiple technological approaches to gain mechanistic insight. Here we review recent progress in the use of advanced mouse genetics in combination with proteomic and transcriptomic approaches to gain a more complete understanding of signaling mechanism in vivo. Integrating insights from such disparate approaches provides advantages in continuing to advance our understanding of how this multifarious group of signaling molecules functions in a diverse array of biological contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.