Trial reportDiabetes care2012
Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy.
Trial report in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research.Biomolecules & biomedicine · 2023Pooled it
- Bariatric Surgery in Adults with Obesity: the Impact on Performance, Metabolism, and Health Indices.Obesity surgery · 2021Pooled it
- Ongoing Inconsistencies in Weight Loss Reporting Following Bariatric Surgery: a Systematic Review.Obesity surgery · 2019Pooled it
- Comparative impact of Roux-en-Y gastric bypass, sleeve gastrectomy or diet alone on beta-cell function in insulin-treated type 2 diabetes patients.Scientific reports · 2024Trial
- Changes in glycemia, insulin and gut hormone responses to a slowly ingested solid low-carbohydrate mixed meal after laparoscopic gastric bypass or band surgery.International journal of obesity (2005) · 2017Trial
- Improvements in glycemic control after gastric bypass occur despite persistent adipose tissue inflammation.Obesity (Silver Spring, Md.) · 2016Trial
- Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids.The Journal of clinical endocrinology and metabolism · 2015Trial
- Clinical trial demonstrates exercise following bariatric surgery improves insulin sensitivity.The Journal of clinical investigation · 2015Trial
- Early weight regain after gastric bypass does not affect insulin sensitivity but is associated with elevated ghrelin.Obesity (Silver Spring, Md.) · 2014Trial
- A prospective randomized study comparing patients with morbid obesity submitted to sleeve gastrectomy with or without omentectomy.Obesity surgery · 2013Trial
- Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet.Clinical obesity · 2025Observational
- Evaluation of the Effects of Postsleeve Gastrectomy Exercise on Long-Term Glucose Profile and Weight Loss Among Iranian Females: A Prospective Cohort Study From 2016 to 2020.Health science reports · 2025Article
- Integrated Insights into Metabolic and Bariatric Surgery: Improving Life Quality and Reducing Mortality in Obesity.Medicina (Kaunas, Lithuania) · 2024Review
- Bariatric Surgery in Obesity: Metabolic Quality Analysis and Comparison of Surgical Options.Advances in experimental medicine and biology · 2024Review
- Article
- Caloric Restriction and Weight Loss Are Primary Factors in the Early Tissue-Specific Metabolic Changes After Bariatric Surgery.Diabetes care · 2022Article
- Bile acids and metabolic surgery.Liver research (Beijing, China) · 2021Review
- Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells.The Journal of clinical investigation · 2020Article
- Portal Venous Metabolite Profiling After RYGB in Male Rats Highlights Changes in Gut-Liver Axis.Journal of the Endocrine Society · 2020Article
- Roux-en-Y gastric bypass surgery improves hepatic glucose metabolism and reduces plasma kisspeptin levels in morbidly obese patients with type 2 diabetes.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveEarly after Roux-en-Y gastric bypass (RYGB), there is improvement in type 2 diabetes, which is characterized by insulin resistance. We determined the acute effects of RYGB, with and without omentectomy, on hepatic and peripheral insulin sensitivity. We also investigated whether preoperative diabetes or postoperative diabetes remission influenced tissue-specific insulin sensitivity after RYGB. RESEARCH DESIGN AND
methodsWe studied 40 obese (BMI 48 ± 8 kg/m(2)) participants, 17 with diabetes. Participants were randomized to RYGB alone or in conjunction with omentectomy. Hyperinsulinemic-euglycemic clamps with isotopic-tracer infusion were completed at baseline and at 1 month postoperatively to assess insulin sensitivity.
resultsParticipants lost 11 ± 4% of body weight at 1 month after RYGB, without an improvement in peripheral insulin sensitivity; these outcomes were not affected by omentectomy, preoperative diabetes, or remission of diabetes. Hepatic glucose production (HGP) and the hepatic insulin sensitivity index improved in all subjects, irrespective of omentectomy (P ≤ 0.001). Participants with diabetes had higher baseline HGP values (P = 0.003) that improved to a greater extent after RYGB (P = 0.006). Of the 17 participants with diabetes, 10 (59%) had remission at 1 month. Diabetes remission had a group × time effect (P = 0.041) on HGP; those with diabetes remission had lower preoperative and postoperative HGP.
conclusionsPeripheral insulin sensitivity did not improve 1 month after RYGB, irrespective of omentectomy, diabetes, or diabetes remission. Hepatic insulin sensitivity improved at 1 month after RYGB and was more pronounced in patients with diabetes. Improvement in HGP may influence diabetes remission early after RYGB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.