ArticleMicrobial cell factories2011
Comparative genomics study of polyhydroxyalkanoates (PHA) and ectoine relevant genes from Halomonas sp. TD01 revealed extensive horizontal gene transfer events and co-evolutionary relationships.
Article in Microbial cell factories, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed.
- Study of Microbial Communities in the Soda Lake of Isabel Island: Identification of Polyhydroxybutyrate (PHB) Degrading Enzymes.Environmental microbiology reports · 2026Article
- Genomic analysis of a novel isolate Vreelandella Titanicae sp. Zn11_249 from the chaotropic environment Salar de Uyuni (Bolivia).BMC genomics · 2026Article
- Genome sequence of Halovibrio sp. HP20-59 as a promising polyhydroxybutyrate producer.Applied microbiology and biotechnology · 2026Article
- Establishing a reference cultivation protocol for systematic characterisation of theFrontiers in bioengineering and biotechnology · 2026Article
- Polyhydroxyalkanoate (PHA) production by landfill isolate Priestia sp. revealed by preparatory glucose-induced tests and genome-annotations.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Halomonas sp. MC140, a polyhydroxyalkanoate (PHA) producer isolated from the Arctic environment.Scientific reports · 2025Article
- Impact of Fermentation on Bacterial and Fungal Microbiome Interactions inInternational journal of food science · 2025Article
- Reconstruction and analyses of genome-scaleMetabolic engineering communications · 2024Article
- Isolation and characterization of aApplied and environmental microbiology · 2024Article
- EngineeringFrontiers in bioengineering and biotechnology · 2023Article
- Whole-genome sequencing and genome-scale metabolic modeling of Chromohalobacter canadensis 85B to explore its salt tolerance and biotechnological use.MicrobiologyOpen · 2022Article
- Development and Application of Transcription Terminators for Polyhydroxylkanoates Production in HalophilicFrontiers in microbiology · 2022Article
- Extremophilic BacteriumFrontiers in bioengineering and biotechnology · 2022Article
- High natural PHA production from acetate in Cobetia sp. MC34 and Cobetia marina DSM 4741Microbial cell factories · 2021Article
- Sea-Ice BacteriaApplied and environmental microbiology · 2021Article
- Thalassobacillus, a genus of extreme to moderate environmental halophiles with biotechnological potential.World journal of microbiology & biotechnology · 2021Review
- Cost-Effective Production of L-DOPA by Tyrosinase-Immobilized Polyhydroxyalkanoate Nanogranules in EngineeredMolecules (Basel, Switzerland) · 2021Article
- Genome analysis of a halophilic bacterium Halomonas malpeensis YU-PRIM-29Scientific reports · 2021Article
- Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine.Nature communications · 2020Article
- Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory.Microbial cell factories · 2020Review
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7 authors.
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Abstract
backgroundHalophilic bacteria have shown their significance in industrial production of polyhydroxyalkanoates (PHA) and are gaining more attention for genetic engineering modification. Yet, little information on the genomics and PHA related genes from halophilic bacteria have been disclosed so far.
resultsThe draft genome of moderately halophilic bacterium, Halomonas sp. TD01, a strain of great potential for industrial production of short-chain-length polyhydroxyalkanoates (PHA), was analyzed through computational methods to reveal the osmoregulation mechanism and the evolutionary relationship of the enzymes relevant to PHA and ectoine syntheses. Genes involved in the metabolism of PHA and osmolytes were annotated and studied in silico. Although PHA synthase, depolymerase, regulator/repressor and phasin were all involved in PHA metabolic pathways, they demonstrated different horizontal gene transfer (HGT) events between the genomes of different strains. In contrast, co-occurrence of ectoine genes in the same genome was more frequently observed, and ectoine genes were more likely under coincidental horizontal gene transfer than PHA related genes. In addition, the adjacent organization of the homologues of PHA synthase phaC1 and PHA granule binding protein phaP was conserved in the strain TD01, which was also observed in some halophiles and non-halophiles exclusively from γ-proteobacteria. In contrast to haloarchaea, the proteome of Halomonas sp. TD01 did not show obvious inclination towards acidity relative to non-halophilic Escherichia coli MG1655, which signified that Halomonas sp. TD01 preferred the accumulation of organic osmolytes to ions in order to balance the intracellular osmotic pressure with the environment.
conclusionsThe accessibility of genome information would facilitate research on the genetic engineering of halophilic bacteria including Halomonas sp. TD01.
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