ArticlePloS one2011
Identification of human NK17/NK1 cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Natural killer (NK) cell deficit in coronary artery disease: no aberrations in phenotype but sustained reduction of NK cells is associated with low-grade inflammation.Clinical and experimental immunology · 2014Trial
- Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies.Frontiers in immunology · 2025Article
- Unveiling Immunomodulatory Effects ofJournal of microbiology and biotechnology · 2024Article
- Interleukin-17 producing cells in swine induced by microbiota during the early postnatal period - a brief research report.Frontiers in immunology · 2023Article
- Decidual CXCR4Clinical and translational medicine · 2021Article
- Drugs for Multiple Sclerosis Activate Natural Killer Cells: Do They Protect Against COVID-19 Infection?Infection and drug resistance · 2020Review
- KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects.Molecular immunology · 2019Article
- Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis.JCI insight · 2018Article
- The Response of IL-17-Producing B Cells to ArtinM Is Independent of Its Interaction with TLR2 and CD14.Molecules (Basel, Switzerland) · 2018Article
- Mucocutaneous IL-17 immunity in mice and humans: host defense vs. excessive inflammation.Mucosal immunology · 2018Review
- Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules.Toxins · 2017Review
- The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity.International journal of molecular sciences · 2017Review
- Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ.Scientific reports · 2017Article
- Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56Frontiers in immunology · 2017Article
- Cytokines IL-17 and IL-22 in the host response to infection.Pathogens and disease · 2016Review
- The characteristics of NK cells in Schistosoma japonicum-infected mouse spleens.Parasitology research · 2015Article
- IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice.European journal of immunology · 2015Article
- Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients.Mucosal immunology · 2015Article
- High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.PloS one · 2015Article
- Multiple sclerosis and the role of immune cells.World journal of experimental medicine · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural killer (NK) cells have both cytolytic and immunoregulatory functions. We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK cell subset(s) that secrete these cytokines is not known. METHODOLOGY/PRINCIPAL
findingsTo isolate the cells secreting IL-17 and IFN-γ, we took advantage of the findings that Th17/Th1 cells express chemokine receptors. Therefore, CD56(+)NK cells were stained with antibodies against various chemokine receptors and intracellularly with antibodies toward IL-17 and IFN-γ. Consequently, we identified previously unrecognized subset of NK cells generated from normal human peripheral blood after activation with IL-2 but not PMA plus ionomycin. The cells are characterized by the expression of CD56(+) and CCR4(+), produce IL-17 and IFN-γ and are consequently named NK17/NK1 cells. They also express CD161, NKp30, NKp44, NKp46, NKG2D, CD158, CCL22, IL-2Rβ and the common γ chain but not CD127 or IL-23R. Further, they possess T-bet and RORγt transcription factors. Antibodies to IL-1β, IL-6, IL-21, or TGF-β1 do not inhibit IL-2-induced generation of NK17/NK1 cells, suggesting that IL-2 has the capacity to polarize these cells. Notably, NK17/NK1 cells are abundant in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) without activation, and are generated from the peripheral blood of these patients after activation with IL-2. CONCLUSIONS/SIGNIFICANCE: NK17/NK1 cells identified here have not been previously described in healthy or MS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.