ArticlePloS one2011
Effects of artesunate on parasite recrudescence and dormancy in the rodent malaria model Plasmodium vinckei.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Pharmacokinetics and pharmacodynamics of oral artesunate monotherapy in patients with uncomplicated Plasmodium falciparum malaria in western Cambodia.Antimicrobial agents and chemotherapy · 2012Trial
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- Isolation and characterization ofAntimicrobial agents and chemotherapy · 2025Article
- Gefitinib as an antimalarial: unveiling its therapeutic potential.Inflammopharmacology · 2025Article
- The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience.Nature communications · 2024Article
- Molecular Mechanisms of Persistence in Protozoan Parasites.Microorganisms · 2023Review
- An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria.The Journal of antimicrobial chemotherapy · 2023Article
- Review
- Chloroquine-susceptible and -resistant Plasmodium falciparum strains survive high chloroquine concentrations by becoming dormant but are eliminated by prolonged exposure.The Journal of antimicrobial chemotherapy · 2022Article
- Article
- PERSISTENCE OF PLASMODIUMAnnals of Ibadan postgraduate medicine · 2021Article
- Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites.BMC biology · 2021Article
- Challenges in forming inferences from limited data: a case study of malaria parasite maturation.Journal of the Royal Society, Interface · 2021Article
- Daily rhythms of both host and parasite affect antimalarial drug efficacy.Evolution, medicine, and public health · 2021Article
- Molecular Mechanisms of Drug Resistance inAnnual review of microbiology · 2020Review
- Rodent malaria in Gabon: Diversity and host range.International journal for parasitology. Parasites and wildlife · 2019Article
- Upregulation of gametocytogenesis in anti-malarial drug-resistantJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Distinct amino acid and lipid perturbations characterize acute versus chronic malaria.JCI insight · 2019Article
- Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro.Antimicrobial agents and chemotherapy · 2018Article
- Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Artemisinin (ART) is the recommended first line therapy for treating uncomplicated and drug-resistant Plasmodium falciparum, the most pathogenic form of malaria. However, treatment failure following ART monotherapy is not uncommon and resistance to this rapidly acting drug has been reported in the Thai-Cambodian border. Recent in vitro studies have shown that following treatment with dihydroartemisinin (DHA), the development of ring-stage parasites is arrested for up to 20 days. These arrested (i.e. dormant) rings could be responsible for the recrudescence of infection that is observed following ART monotherapy. To develop a better understanding of the stage-specific effects of ART and determine if dormancy occurs in vivo, the ART derivative artesunate (AS) was used to treat mice infected with the synchronous rodent malaria parasites P. vinckei petteri (non-lethal) and P. v. vinckei (lethal). Results show that in both the non-lethal and lethal strains, ring-stage parasites are the least susceptible to treatment with AS and that the day of treatment has more of an impact on recrudescence than the total dose administered. Additionally, 24 hrs post-treatment with AS, dormant forms similar in morphology to those seen in vitro were observed. Finally, rate of recrudescence studies suggest that there is a positive correlation between the number of dormant parasites present and when recrudescence occurs in the vertebrate host. Collectively, these data suggest that dormancy occurs in vivo and contributes to recrudescence that is observed following AS treatment. It is possible that this may represent a novel mechanism of parasite survival following treatment with AS.
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