ArticlePloS one2011
Determinants of functional coupling between astrocytes and respiratory neurons in the pre-Bötzinger complex.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Glutamate tone in preBötzinger complex rhythmogenesis: ambient extracellular glutamate as a candidate excitability bias.Pflugers Archiv : European journal of physiology · 2026Review
- Review
- Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2-EAAT2 apposition in the preBötzinger complex.Histochemistry and cell biology · 2026Article
- Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex.CNS neuroscience & therapeutics · 2025Article
- Article
- CaFrontiers in cellular neuroscience · 2025Review
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Cell types and synchronous-activity patterns of inspiratory neurons in the preBötzinger complex of mouse medullary slices during early postnatal development.Scientific reports · 2023Article
- Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation.Frontiers in physiology · 2023Article
- Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling.Frontiers in cellular neuroscience · 2023Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- On the electrical passivity of astrocyte potassium conductance.Journal of neurophysiology · 2021Review
- The postnatal development of ultrasonic vocalization-associated breathing is altered in glycine transporter 2-deficient mice.The Journal of physiology · 2019Article
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey.The Journal of physiology · 2017Article
- Article
- Organotypic slice cultures containing the preBötzinger complex generate respiratory-like rhythms.Journal of neurophysiology · 2016Article
- GlyT2-Dependent Preservation of MECP2-Expression in Inhibitory Neurons Improves Early Respiratory Symptoms but Does Not Rescue Survival in a Mouse Model of Rett Syndrome.Frontiers in physiology · 2016Article
- Automated cell-specific laser detection and ablation of neural circuits in neonatal brain tissue.The Journal of physiology · 2013Article
- Astrocyte-neuron communication: functional consequences.Neurochemical research · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory neuronal network activity is thought to require efficient functioning of astrocytes. Here, we analyzed neuron-astrocyte communication in the pre-Bötzinger Complex (preBötC) of rhythmic slice preparations from neonatal mice. In astrocytes that exhibited rhythmic potassium fluxes and glutamate transporter currents, we did not find a translation of respiratory neuronal activity into phase-locked astroglial calcium signals. In up to 20% of astrocytes, 2-photon calcium imaging revealed spontaneous calcium fluctuations, although with no correlation to neuronal activity. Calcium signals could be elicited in preBötC astrocytes by metabotropic glutamate receptor activation or after inhibition of glial glutamate uptake. In the latter case, astrocyte calcium elevation preceded a surge of respiratory neuron discharge activity followed by network failure. We conclude that astrocytes do not exhibit respiratory-rhythmic calcium fluctuations when they are able to prevent synaptic glutamate accumulation. Calcium signaling is, however, observed when glutamate transport processes in astrocytes are suppressed or neuronal discharge activity is excessive.
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