ArticlePLoS biology2011
Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration.Nature physics · 2026Article
- Position-dependent feedback drives scaling and robustness of morphogen gradients.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Differential sensitivity of midline development to mitosis during and after primitive streak extension.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Drosophila Dpp and BMP signaling directly regulates dpp transcription for optimal ligand production.Development (Cambridge, England) · 2025Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling ineLife · 2024Article
- Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling inbioRxiv : the preprint server for biology · 2024Article
- Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.Nature communications · 2024Article
- Review
- Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo.Development (Cambridge, England) · 2024Article
- Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.Nature communications · 2023Article
- Article
- SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.PLoS biology · 2023Article
- Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila.Scientific reports · 2023Article
- The impact of cell size on morphogen gradient precision.Development (Cambridge, England) · 2023Article
- Article
- The nested embryonic dorsal domains of BMP-target genes are not scaled to size during the evolution of Drosophila species.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Article
- Azot expression in theCommunicative & integrative biology · 2023Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The wing of the fruit fly, Drosophila melanogaster, with its simple, two-dimensional structure, is a model organ well suited for a systems biology approach. The wing arises from an epithelial sac referred to as the wing imaginal disc, which undergoes a phase of massive growth and concomitant patterning during larval stages. The Decapentaplegic (Dpp) morphogen plays a central role in wing formation with its ability to co-coordinately regulate patterning and growth. Here, we asked whether the Dpp signaling activity scales, i.e. expands proportionally, with the growing wing imaginal disc. Using new methods for spatial and temporal quantification of Dpp activity and its scaling properties, we found that the Dpp response scales with the size of the growing tissue. Notably, scaling is not perfect at all positions in the field and the scaling of target gene domains is ensured specifically where they define vein positions. We also found that the target gene domains are not defined at constant concentration thresholds of the downstream Dpp activity gradients P-Mad and Brinker. Most interestingly, Pentagone, an important secreted feedback regulator of the pathway, plays a central role in scaling and acts as an expander of the Dpp gradient during disc growth.
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