ArticleChemical senses2012
Genetic variation in odorant receptors contributes to variation in olfactory behavior in a natural population of Drosophila melanogaster.
Article in Chemical senses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Phenethyl Acetate as an Agonist of Insect Odorant Receptor Co-Receptor (Orco): Molecular Mechanisms and Functional Insights.International journal of molecular sciences · 2025Article
- Shedding Light on Inter-Individual Variability of Olfactory Circuits inFrontiers in behavioral neuroscience · 2022Review
- Mechanisms of Variability Underlying Odor-Guided Locomotion.Frontiers in behavioral neuroscience · 2022Review
- Natural variation at theOpen biology · 2021Article
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- Molecular and Functional Evolution at the Odorant Receptor Or22 Locus in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption.BMC genomics · 2017Article
- Current source density mapping of antennal sensory selectivity reveals conserved olfactory systems between tephritids and Drosophila.Scientific reports · 2017Article
- Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species.Scientific reports · 2017Article
- Population differences in olfaction accompany host shift in Drosophila mojavensis.Proceedings. Biological sciences · 2016Article
- Rapid evolution of chemosensory receptor genes in a pair of sibling species of orchid bees (Apidae: Euglossini).BMC evolutionary biology · 2015Article
- Saccharomyces cerevisiae mitochondria are required for optimal attractiveness to Drosophila melanogaster.PloS one · 2014Article
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- Novel oxidatively activated agents modify DNA and are enhanced by ercc1 silencing.Chemical research in toxicology · 2012Article
- Personal receptor repertoires: olfaction as a model.BMC genomics · 2012Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Chemoreception is a principle modality by which organisms gain information from their environment, and extensive variation in odor-mediated behavior has been documented within and among species. To examine the mechanisms by which sensory systems mediate these responses, we ask to what extent variation in Drosophila melanogaster odorant receptor genes contributes to variation in odor-mediated behavior. Significant differences in behavioral responses to structurally similar odorants, methyl hexanoate and ethyl hexanoate, were found in a natural population. Polymorphisms in 3 genomic regions (Or22a/Or22b, Or35a, and Or47a) were identified and associated with variation in behavior to these esters. Overall similarity in association profiles for both odorants was observed, except for Or47a in which polymorphisms were associated solely with variation in responses to ethyl hexanoate. Our analyses were then extended to examine polymorphisms in 3 odorant receptors previously reported to contribute to variation in olfactory behavior for the chemically distinct odorants benzaldehyde and acetophenone. Two Or10a polymorphisms were associated with variation in response to ethyl hexanoate. Finally, differences in Or35a and Or47a expression were associated with variation in responses to ethyl hexanoate. These results demonstrate that the genetic variation at the peripheral sensory stage plays a role in mediating differences in odor-mediated behavior.
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