ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2012
SIRT1 inhibits the mouse intestinal motility and epithelial proliferation.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Probiotic efficacy of Cetobacterium somerae (CGMCC No. 28843): promoting intestinal digestion, absorption, and structural integrity in juvenile grass carp (Ctenopharyngodon idella).Journal of animal science and biotechnology · 2025Article
- Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle.Pflugers Archiv : European journal of physiology · 2025Review
- SVHRSP Alleviates Age-Related Cognitive Deficiency by Reducing Oxidative Stress and Neuroinflammation.Antioxidants (Basel, Switzerland) · 2024Article
- A Potential Role for Sirtuin-1 in Alzheimer's Disease: Reviewing the Biological and Environmental Evidence.Journal of Alzheimer's disease reports · 2023Review
- Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System.Frontiers in neuroscience · 2020Review
- Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.The American journal of pathology · 2020Article
- Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota.Molecules (Basel, Switzerland) · 2018Article
- The Crosstalk between the Gut Microbiota and Mitochondria during Exercise.Frontiers in physiology · 2017Review
- Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway.International journal of clinical and experimental pathology · 2015Article
- Sirt1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction.PloS one · 2013Article
- Reelin is involved in the crypt-villus unit homeostasis.Tissue engineering. Part A · 2013Article
- GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility.American journal of physiology. Endocrinology and metabolism · 2012Article
- 2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.PloS one · 2012Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Sirtuin 1 (SIRT1), a NAD(+)-dependent histone deacetylase, is involved in a wide array of cellular processes including glucose homeostasis, energy metabolism, proliferation and apoptosis, and immune response. However, it is unknown whether SIRT1 plays any physiological role in the regulation of intestinal homeostasis and motility. Thus the aim was to define SIRT1 expression and function in the gastrointestinal (GI) tract under physiological conditions. Forty 12-14-wk-old SIRT1 knockout (KO) and wild-type (WT) mice were fasted 21 h and/or refed 3 h. Fasted mice were injected intraperitoneally with bromodeoxyuridine (120 mg/kg body wt) 2 h before euthanasia. SIRT1 protein was localized to gastric and intestinal epithelial nuclei and was responsive to the nutritional status. SIRT1 was required for intestinal epithelial homeostasis. The SIRT1 KO mice showed enhanced crypt proliferation and suppressed villous apoptosis, resulting in increased intestinal villous height. In the SIRT1 KO intestine, the abundance of Forkhead box protein O1 and p53 protein decreased, whereas the subcellular localization of β-catenin protein accumulated mainly in the crypts. The SIRT1 KO mice showed accelerated gastric emptying rate with increased abundance of ghrelin mRNA and protein in the stomach. Moreover, the SIRT1 KO mouse intestine showed enhanced ex vivo spontaneous contraction. We concluded that, SIRT1 plays a critical role in the control of intestinal homeostasis (by promoting apoptosis and inhibiting proliferation) and gastrointestinal motility (by reducing gastric emptying and intestinal contractile activity), implicating a novel role for SIRT1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.