ArticleDevelopmental neurobiology2012
Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia.
Article in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Glia generate distinct visual processing centres by locally inhibiting ERK activity in an optic lobe neuroepithelium.bioRxiv : the preprint server for biology · 2026Article
- Article
- A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.PLoS genetics · 2023Article
- Review
- Circuit analysis reveals a neural pathway for light avoidance in Drosophila larvae.Nature communications · 2022Article
- Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized.The Journal of cell biology · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- Article
- The proneural wave in theeLife · 2019Article
- Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System.Frontiers in molecular neuroscience · 2019Review
- Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.Neural development · 2018Article
- Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.PLoS genetics · 2018Article
- Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain.Neural development · 2014Article
- Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe.PloS one · 2014Article
- Evidence for tissue-specific Jak/STAT target genes in Drosophila optic lobe development.Genetics · 2013Article
- Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division.Development (Cambridge, England) · 2012Article
- Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb.Developmental biology · 2012Article
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3 authors at 1 institution in 1 country.
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Abstract
A dynamic balance between stem cell maintenance and differentiation paces generation of post-mitotic progeny during normal development and maintenance of homeostasis. Recent studies show that Notch plays a key role in regulating the identity of neuroepithelial stem cells, which generate terminally differentiated neurons that populate the adult optic lobe via the intermediate progenitor cell type called neuroblast. Thus, understanding how Notch controls neuroepithelial cell maintenance and neuroblast formation will provide critical insight into the intricate regulation of stem cell function during tissue morphogenesis. Here, we showed that a low level of Notch signaling functions to maintain the neuroepithelial cell identity by suppressing the expression of pointedP1 gene through the transcriptional repressor Anterior open. Increased Notch signaling, which coincides with transient cell cycle arrest but precedes the expression of PointedP1 in cells near the medial edge of neuroepithelia, defines transitioning neuroepithelial cells that are in the process of acquiring the neuroblast identity. Transient up-regulation of Notch signaling in transitioning neuroepithelial cells decreases their sensitivity to PointedP1 and prevents them from becoming converted into neuroblasts prematurely. Down-regulation of Notch signaling combined with a high level of PointedP1 trigger a synchronous conversion from transitioning neuroepithelial cells to immature neuroblasts at the medial edge of neuroepithelia. Thus, changes in Notch signaling orchestrate a dynamic balance between maintenance and conversion of neuroepithelial cells during optic lobe neurogenesis.
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