Evidence map›Paper›PMID 22038707›Full record

ArticleElectrophoresis2011

Integration of microchip electrophoresis with electrochemical detection using an epoxy-based molding method to embed multiple electrode materials.

Alicia S Johnson, Asmira Selimovic, R Scott Martin

Open access · greenAbstract read
In one paragraph

Article in Electrophoresis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Integrating 3D Cell Culture of PC12 Cells with Microchip-Based Electrochemical Detection.Analytical methods : advancing methods and applications · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alicia S JohnsonDepartment of Chemistry, Saint Louis University, St. Louis, MO 63103, USA.
Asmira Selimovic
R Scott Martin
Saint Louis University · US

Funding

Microchip-based Cell Reactor/Analysis SystemR15GM084470 · NIGMS · SAINT LOUIS UNIVERSITY · PI MARTIN, ROBERT SCOTT · 2008 to 2019
$1.3M
NIGMS NIH HHS R15 GM084470NIGMS NIH HHS R15GM084470-03
6 · The paper itself

Abstract

This paper describes the use of epoxy-encapsulated electrodes to integrate microchip-based electrophoresis with electrochemical detection. Devices with various electrode combinations can easily be developed. This includes a palladium decoupler with a downstream working electrode material of either gold, mercury/gold, platinum, glassy carbon, or a carbon fiber bundle. Additional device components such as the platinum wires for the electrophoresis separation and the counter electrode for detection can also be integrated into the epoxy base. The effect of the decoupler configuration was studied in terms of the separation performance, detector noise, and the ability to analyze samples of a high ionic strength. The ability of both glassy carbon and carbon fiber bundle electrodes to analyze a complex mixture was demonstrated. It was also shown that a PDMS-based valving microchip can be used along with the epoxy-embedded electrodes to integrate microdialysis sampling with microchip electrophoresis and electrochemical detection, with the microdialysis tubing also being embedded in the epoxy substrate. This approach enables one to vary the detection electrode material as desired in a manner where the electrodes can be polished and modified as is done with electrochemical flow cells used in liquid chromatography.

Indexed as

CatecholsDopamineElectrodesElectrophoresis, MicrochipEpinephrineEpoxy ResinsEquipment DesignMicrodialysisPalladiumcatecholCatecholsDopamineEpinephrineEpoxy ResinsPalladium

Identifiers

PMID22038707
PMCPMC3314886
OpenAlexW2013530275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.