ReviewSleep & breathing = Schlaf & Atmung2012
Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment.
Review in Sleep & breathing = Schlaf & Atmung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03539081 (Investigating Mechanisms of Human Spinal Cord Stimulation for Purpose of Treating Restless Leg Syndrome), which is not on this map. Cited by 75 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Mechanisms of Human Spinal Cord Stimulation for Purpose of Treating Restless Leg Syndrome
Who cites it
75 citing papers in PubMed, 9 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Vitamin D supplementation in later life: a systematic review of efficacy and safety in movement disorders.Frontiers in aging neuroscience · 2024Pooled it
- Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Pooled it
- Large genome-wide association study identifies three novel risk variants for restless legs syndrome.Communications biology · 2020Pooled it
- Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Benzodiazepines for restless legs syndrome.The Cochrane database of systematic reviews · 2017Pooled it
- Opioids for restless legs syndrome.The Cochrane database of systematic reviews · 2016Pooled it
- Efficacy of Pramipexole for the Treatment of Primary Restless Leg Syndrome: A Systematic Review and Meta-analysis of Randomized Clinical Trials.Clinical therapeutics · 2016Pooled it
- Restless legs syndrome in chronic myeloid leukemia: an overlooked condition with a significant impact on health-related quality of life.Annals of hematology · 2026Article
- Restless legs syndrome among third-trimester pregnant women attending ANC Clinic in public hospitals in North Wollo Zone, Ethiopia.PloS one · 2026Article
- The prevalence of restless legs syndrome among university students: a single-centre study.Acta neurologica Belgica · 2025Article
- Sex and age differences in sleep disorders: insights from a diverse cohort referred to a sleep center.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Obstructive Sleep Apnea Syndrome in women: gender in sleep respiratory medicine is a first step towards personalized medicine.Sleep & breathing = Schlaf & Atmung · 2025Review
- Prevalence of Restless Legs Syndrome in Patients Who Underwent Percutaneous Coronary Intervention in a Tertiary Care Hospital: A Cross-Sectional Study.Annals of Indian Academy of Neurology · 2025Article
- Simultaneous evaluation of restless leg syndrome, neuropathic pain, disease activity, and quality of life in patients with Takayasu arteritis: a cross-sectional study.Scientific reports · 2025Article
- Relationship of Autophagic Dysfunction With the Quality of Life and Sleep, Depression and Disease Severity in Patients With Restless Legs Syndrome.Brain and behavior · 2025Article
- [Epidemiology of sleep disorders in rural northern Bénin in 2022].The Pan African medical journal · 2025Article
- A Biobehavioral Perspective on Caring for Allogeneic Hematopoietic Stem Cell Transplant Survivors with Graft-Versus-Host Disease.Transplantation and cellular therapy · 2024Article
- Risk of Suicidal Ideation and Behavior Following Early-Onset Idiopathic Restless Legs Syndrome Treatment.Pharmacoepidemiology and drug safety · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesRestless legs syndrome (RLS) is underdiagnosed and poorly understood by clinicians and the general public alike; accordingly, a broad literature review with information most relevant to general practice is needed to help dispel misconceptions and improve level of care.
methodsSpecifically, this review comprehensively provides an epidemiological analysis of RLS and examines the risk factors and treatment options for RLS by compiling the findings of past RLS studies. These RLS studies were identified through a retrospective PubMed search. The epidemiological analysis was conducted by calculating a weighted mean average of all the relevant general population RLS prevalence studies, separated into geographical/racial categories.
resultsA comprehensive analysis of RLS epidemiological studies finds the prevalence rate of RLS to be 5-15% in the general population with 2.5% of adults having symptoms severe enough to require medical intervention. Some of the risk factors for RLS include female gender, pregnancy, low iron levels, lower socioeconomic status, poor health, elderly age, comorbidity with Parkinson's disease, positive family history of RLS, and comorbidity with psychiatric disorders. A wide array of treatment options exist for RLS including pharmacological and nonpharmacologic interventions.
conclusionsClinicians' understanding of RLS enigma has recently improved due to the increased intensity of RLS research over the past decade. This review summarizes the current findings in the RLS field as well as providing guidelines for future RLS-related research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.