ArticleJournal of bone and mineral metabolism2012
Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr fa rats.
Article in Journal of bone and mineral metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Fracture risk is increased by the complication of hypertension and treatment with calcium channel blockers in postmenopausal women with type 2 diabetes.Journal of bone and mineral metabolism · 2013Trial
- Article
- Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus.Endocrinology · 2019Article
- Long-term wheel-running can prevent deterioration of bone properties in diabetes mellitus model rats.Journal of musculoskeletal & neuronal interactions · 2017Article
- Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats.Osteoporosis and sarcopenia · 2016Article
- Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats.The Journal of veterinary medical science · 2015Article
- Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice.The Journal of endocrinology · 2014Article
- Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats.Journal of diabetes research · 2014Article
- Diabetic complications in obese type 2 diabetic rat models.Experimental animals · 2014Review
- The spontaneously diabetic torii rat: an animal model of nonobese type 2 diabetes with severe diabetic complications.Journal of diabetes research · 2013Article
- Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Lepr (fa) Rat: A New Obese Type 2 Diabetic Model.Journal of diabetes research · 2013Article
- Hyperinsulinemia reduces osteoblast activity in vitro via upregulation of TGF-β.Journal of molecular medicine (Berlin, Germany) · 2012Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Spontaneously Diabetic Torii-Lepr (fa) (SDT-fa/fa) rat is a new model of obese type 2 diabetes. The SDT-fa/fa rat shows obesity and hyperglycemia at a young age compared to the Spontaneously Diabetic Torii (SDT-+/+) rat; however, bone abnormalities in the SDT-fa/fa rat have not been investigated. The objective of the present study was to investigate the effects of obese type 2 diabetes on bone turnover, bone mass, and bone strength in the SDT-fa/fa rat. Sprague-Dawley rats were used as control animals, and SDT-+/+ rats were used as non-obese type 2 diabetic rats. Serum osteocalcin and urine deoxypyridinoline levels were decreased in SDT-fa/fa rats compared to control rats at a young age. SDT-fa/fa rats showed decreases in bone mineral density and bone mineral content of the whole tibia, and shortening of the tibia and femur compared to control and SDT-+/+ rats. Deterioration in bone geometrical properties of the femur midshaft such as cortical thickness and minimum moment of inertia, was observed in SDT-fa/fa rats compared to control and SDT-+/+ rats. Furthermore, trabecular bone volume of the distal femur was decreased in SDT-fa/fa rats compared to control rats. These negative effects on bone in SDT-fa/fa rats caused severe decreases in maximum load, stiffness, and energy absorption of the femur. In addition, serum levels of homocysteine, a candidate for bone fragility markers, were elevated in SDT-fa/fa rats compared to control and SDT-+/+ rats. In conclusion, the SDT-fa/fa rat may be a useful model to investigate bone abnormalities in obese type 2 diabetes.
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