ReviewClinical and experimental nephrology2012
The role of the kidney in salt-sensitive hypertension.
Review in Clinical and experimental nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Peroxiredoxin 5 Acts as a Negative Regulator of the Sodium-Chloride Cotransporter Involved in Alleviating Angiotensin II-Induced Hypertension.Antioxidants (Basel, Switzerland) · 2025Article
- Cyclosporin-induced hypertension is associated with the up-regulation of Na+-K+-2Cl- cotransporter (NKCC2).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Structural Pharmacology of Cation-Chloride Cotransporters.Membranes · 2022Review
- Alamandine alleviates hypertension and renal damage via oxidative-stress attenuation in Dahl rats.Cell death discovery · 2022Article
- Urine concentrating defect as presenting sign of progressive renal failure in Bardet-Biedl syndrome patients.Clinical kidney journal · 2021Article
- Urinary proteomics reveals key markers of salt sensitivity in hypertensive patients during saline infusion.Journal of nephrology · 2021Article
- A case series of adult patients affected by EAST/SeSAME syndrome suggests more severe disease in subjects bearingIntractable & rare diseases research · 2021Article
- SLC12A8 plays a key role in bladder cancer progression and EMT.Open medicine (Warsaw, Poland) · 2021Article
- Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R-V2R mutation.Scientific reports · 2020Article
- Exploring Key Challenges of Understanding the Pathogenesis of Kidney Disease in Bardet-Biedl Syndrome.Kidney international reports · 2020Review
- Review
- ERK1,2 Signalling Pathway along the Nephron and Its Role in Acid-base and Electrolytes Balance.International journal of molecular sciences · 2019Review
- Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles.Journal of the American Heart Association · 2019Article
- Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension.Physiological reviews · 2019Review
- The importance of the thick ascending limb of Henle's loop in renal physiology and pathophysiology.International journal of nephrology and renovascular disease · 2018Review
- New Findings on the Pathogenesis of Distal Renal Tubular Acidosis.Kidney diseases (Basel, Switzerland) · 2017Review
- Antihypertensive effect of Ganjang (traditional Korean soy sauce) on Sprague-Dawley Rats.Nutrition research and practice · 2017Article
- Acute genetic ablation of pendrin lowers blood pressure in mice.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension.BBA clinical · 2014Article
- Physiology and pathophysiology of SLC12A1/2 transporters.Pflugers Archiv : European journal of physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary hypertension is one of the leading risk factors for cardiovascular disease. Although the pathogenesis is not completely understood, an imbalance of sodium and chloride homeostasis seems to be relevant both in the induction and in the maintenance of salt-sensitive hypertension. Besides individual renal phenotypes, salt intake is one of the most important environmental determinants of this condition. The Milan hypertensive strain (MHS) of rats is an interesting model to investigate the molecular mechanisms underling the development of salt-sensitive hypertension. In young MHS rats, hypertension is anticipated by a phase of increased salt reabsorption localized along the medullary thick ascending limb associated with the up-regulation of the apical sodium-potassium-chloride cotransporter (NKCC2). Later, the frank hypertensive status of adult MHS rats is accompanied by the activation of the luminal and basal lateral transporters of sodium chloride (NaCl) in the distal convoluted tubule (DCT). Several lines of evidence have proven the key role of DCT in the maintenance of hypertension in MHS rats; more importantly, hypertensive patients carrying a mutation of α-adducin (resembling the MHS model) have a high sensitivity to thiazides, suggesting that the Na(+)-Cl(-) cotransporter also plays a pivotal role in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.