ArticleJPEN. Journal of parenteral and enteral nutrition2012
Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis.
Article in JPEN. Journal of parenteral and enteral nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019Guideline
- Low-Dose Parenteral Soybean Oil for the Prevention of Parenteral Nutrition-Associated Liver Disease in Neonates With Gastrointestinal Disorders.JPEN. Journal of parenteral and enteral nutrition · 2017Trial
- A medium-chain fatty acid analogue prevents endotoxin liver injury in a murine model.Scientific reports · 2025Article
- Liver magnetic resonance spectroscopy as an alternative for evaluating Niemann-Pick C disease progression.RSC advances · 2025Article
- Risk of Liver Injury Associated with Intravenous Lipid Emulsions: A Prescription Sequence Symmetry Analysis.Frontiers in pharmacology · 2021Article
- Fish oil-based injectable lipid emulsions containing medium-chain triglycerides or added α-tocopherol offer anti-inflammatory benefits in a murine model of parenteral nutrition-induced liver injury.The American journal of clinical nutrition · 2019Article
- Article
- Redefining essential fatty acids in the era of novel intravenous lipid emulsions.Clinical nutrition (Edinburgh, Scotland) · 2018Review
- Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats.Scientific reports · 2017Article
- Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient: Understanding the Differences.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2016Review
- The Essentiality of Arachidonic Acid in Infant Development.Nutrients · 2016Review
- Long-chain polyunsaturated fatty acids and the preterm infant: a case study in developmentally sensitive nutrient needs in the United States.The American journal of clinical nutrition · 2016Review
- The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice.Metabolism: clinical and experimental · 2015Article
- Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target?The Journal of surgical research · 2014Article
- The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model.Metabolism: clinical and experimental · 2013Article
- Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids.Aging cell · 2012Article
- The use of fish oil lipid emulsion in the treatment of intestinal failure associated liver disease (IFALD).Nutrients · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesEssential fatty acids are important for growth, development, and physiologic function. α-Linolenic acid and linoleic acid are the precursors of docosahexaenoic and arachidonic acid, respectively, and have traditionally been considered the essential fatty acids. However, the authors hypothesized that docosahexaenoic acid and arachidonic acid can function as the essential fatty acids.
methodsUsing a murine model of essential fatty acid deficiency and consequent hepatic steatosis, the authors provided mice with varying amounts of docosahexaenoic and arachidonic acids to determine whether exclusive supplementation of docosahexaenoic and arachidonic acids could prevent essential fatty acid deficiency and inhibit or attenuate hepatic steatosis.
resultsMice supplemented with docosahexaenoic and arachidonic acids at 2.1% or 4.2% of their calories for 19 days had normal liver histology and no biochemical evidence of essential fatty acid deficiency, which persisted when observed after 9 weeks.
conclusionSupplementation of sufficient amounts of docosahexaenoic and arachidonic acids alone without α-linolenic and linoleic acids meets essential fatty acid requirements and prevents hepatic steatosis in a murine model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.