ArticleSurgical endoscopy2012
CO2 pneumoperitoneum impact on early liver and lung cytokine expression in a rat model of abdominal sepsis.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- COPediatric surgery international · 2022Article
- The effect of glutathione as adjuvant therapy on levels of TNF-α and IL-10 in wistar rat peritonitis model.Annals of medicine and surgery (2012) · 2021Article
- High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice.Mediators of inflammation · 2020Article
- Article
- Relaparoscopy for management of postoperative complications following colorectal surgery: ten years experience in a single center.Surgical endoscopy · 2015Article
- Management of Complications Following Emergency and Elective Surgery for Diverticulitis.Viszeralmedizin · 2015Review
- CO2 pneumoperitoneum preserves β-arrestin 2 content and reduces high mobility group box-1 (HMGB-1) expression in an animal model of peritonitis.Oxidative medicine and cellular longevity · 2015Article
- Advances in sepsis-associated liver dysfunction.Burns & trauma · 2014Article
- In vitro CO2-induced ROS production impairs cell cycle in SH-SY5Y neuroblastoma cells.Pediatric surgery international · 2013Article
Corrections and comments
- Expression of concern · 2023-02-14Author Unresponsive · Concerns/Issues about Image ·
- Expression of concern
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperimental evidence suggests that laparoscopy could have reduced inflammatory sequelae compared with laparotomy following abdominal surgery for peritonitis. The aim of the present study is to investigate the possible beneficial effects of CO(2) insufflation on liver and lung expression of proinflammatory cytokines during sepsis.
methodsCecal ligation and puncture (CLP) was induced in Sprague-Dawley rats, and 6 h later rats were randomly subjected to CO(2) pneumoperitoneum (5-7 mmHg) or to laparotomy for 1 h. At the end of the CO(2) pneumoperitoneum or laparotomy procedures, animals were sacrificed, and liver and lung were removed and stored for molecular and histological analysis.
resultsLiver and lung expression of proinflammatory cytokines was significantly reduced in animals subjected to CO(2) pneumoperitoneum compared with laparotomy. In particular, tumor necrosis factor-alpha (TNF-α) protein expression was significantly reduced (p < 0.05) following CO(2) pneumoperitoneum compared with laparotomy procedures. Interleukin (IL)-6 protein expression was accordingly, markedly reduced (p < 0.05) following CO(2) pneumoperitoneum. Histological analysis showed a reduced inflammatory infiltrate in liver and lung from animals subjected to CO(2) pneumoperitoneum compared with laparotomy.
conclusionsOur results support the hypothesis that laparoscopic procedures reduce the inflammatory cascade, following peritoneal sepsis, via reduced expression of proinflammatory cytokines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.