ArticleCancer research2011
Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium.
Article in Cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pooled it
- Association between common polymorphisms in ERCC gene and glioma risk: A meta-analysis of 15 studies.Medicine · 2017Pooled it
- Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer.Human molecular genetics · 2013Pooled it
- Whole genome sequencing-based analysis of genetic predisposition to adult glioblastoma.NPJ genomic medicine · 2025Article
- Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.Scientific reports · 2024Article
- Population Neuroscience: Principles and Advances.Current topics in behavioral neurosciences · 2024Review
- The genomic landscape of familial glioma.Science advances · 2023Article
- Genome-wide analysis of high-risk primary brain cancer pedigrees identifies PDXDC1 as a candidate brain cancer predisposition gene.Neuro-oncology · 2021Article
- Genetic and molecular epidemiology of adult diffuse glioma.Nature reviews. Neurology · 2019Review
- The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database.BMC cancer · 2019Article
- Decreased expression of miR-410-3p correlates with poor prognosis and tumorigenesis in human glioma.Cancer management and research · 2019Article
- Molecular subtyping of tumors from patients with familial glioma.Neuro-oncology · 2018Article
- Pediatric High Grade Gliomas in the Context of Cancer Predisposition Syndromes.Journal of Korean Neurosurgical Society · 2018Review
- Article
- The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.Neuro-oncology · 2015Article
- New insights into the genetics of glioblastoma multiforme by familial exome sequencing.Oncotarget · 2015Article
- Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.Scientific reports · 2015Article
- Survival and low-grade glioma: the emergence of genetic information.Neurosurgical focus · 2015Article
- The epidemiology of glioma in adults: a "state of the science" review.Neuro-oncology · 2014Review
- Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.Human molecular genetics · 2013Article
Corrections and comments
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Authors and funding
29 authors at 6 institutions in 2 countries.
Funding
Abstract
Gliomas, which generally have a poor prognosis, are the most common primary malignant brain tumors in adults. Recent genome-wide association studies have shown that inherited susceptibility plays a role in the development of glioma. Although first-degree relatives of patients exhibit a two-fold increased risk of glioma, the search for susceptibility loci in familial forms of the disease has been challenging because the disease is relatively rare, fatal, and heterogeneous, making it difficult to collect sufficient biosamples from families for statistical power. To address this challenge, the Genetic Epidemiology of Glioma International Consortium (Gliogene) was formed to collect DNA samples from families with two or more cases of histologically confirmed glioma. In this study, we present results obtained from 46 U.S. families in which multipoint linkage analyses were undertaken using nonparametric (model-free) methods. After removal of high linkage disequilibrium single-nucleotide polymorphism, we obtained a maximum nonparametric linkage score (NPL) of 3.39 (P = 0.0005) at 17q12-21.32 and the Z-score of 4.20 (P = 0.000007). To replicate our findings, we genotyped 29 independent U.S. families and obtained a maximum NPL score of 1.26 (P = 0.008) and the Z-score of 1.47 (P = 0.035). Accounting for the genetic heterogeneity using the ordered subset analysis approach, the combined analyses of 75 families resulted in a maximum NPL score of 3.81 (P = 0.00001). The genomic regions we have implicated in this study may offer novel insights into glioma susceptibility, focusing future work to identify genes that cause familial glioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.