ReviewAge (Dordrecht, Netherlands)2013
Genes and the ageing muscle: a review on genetic association studies.
Review in Age (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Progressive Resistance Training for Concomitant Increases in Muscle Strength and Bone Mineral Density in Older Adults: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin.GeroScience · 2021Trial
- Trial
- ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults.BioMed research international · 2017Trial
- Sarcopenia and its Cognitive Consequences: Insights from an Urban Indian Cohort.Annals of Indian Academy of Neurology · 2025Article
- Pathophysiology of Myopenia in rheumatoid arthritis.Bone research · 2025Review
- Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project.The lancet. Healthy longevity · 2023Article
- Beneficial Effect of HInternational journal of molecular sciences · 2022Article
- Prevalence and factors contributing to primary sarcopenia in relatively healthy older Indians attending the outpatient department in a tertiary care hospital: A cross-sectional study.Aging medicine (Milton (N.S.W)) · 2021Article
- Sarcopenia, Obesity, and Sarcopenic Obesity: Relationship with Skeletal Muscle Phenotypes and Single Nucleotide Polymorphisms.Journal of clinical medicine · 2021Article
- Myostatin and Follistatin-New Kids on the Block in the Diagnosis of Sarcopenia in IBD and Possible Therapeutic Implications.Biomedicines · 2021Review
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- Sarcopenia in aging, obesity, and cancer.Translational cancer research · 2020Article
- Strength and Endurance Training in Older Women in Relation toInternational journal of environmental research and public health · 2020Article
- Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women.Journal of cachexia, sarcopenia and muscle · 2019Article
- Polygenic risk score for disability and insights into disability-related molecular mechanisms.GeroScience · 2019Article
- Sarcopenia and fatty liver disease.Hepatology international · 2019Review
- Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.Biogerontology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Western populations are living longer. Ageing decline in muscle mass and strength (i.e. sarcopenia) is becoming a growing public health problem, as it contributes to the decreased capacity for independent living. It is thus important to determine those genetic factors that interact with ageing and thus modulate functional capacity and skeletal muscle phenotypes in older people. It would be also clinically relevant to identify 'unfavourable' genotypes associated with accelerated sarcopenia. In this review, we summarized published information on the potential associations between some genetic polymorphisms and muscle phenotypes in older people. A special emphasis was placed on those candidate polymorphisms that have been more extensively studied, i.e. angiotensin-converting enzyme (ACE) gene I/D, α-actinin-3 (ACTN3) R577X, and myostatin (MSTN) K153R, among others. Although previous heritability studies have indicated that there is an important genetic contribution to individual variability in muscle phenotypes among old people, published data on specific gene variants are controversial. The ACTN3 R577X polymorphism could influence muscle function in old women, yet there is controversy with regards to which allele (R or X) might play a 'favourable' role. Though more research is needed, up-to-date MSTN genotype is possibly the strongest candidate to explain variance among muscle phenotypes in the elderly. Future studies should take into account the association between muscle phenotypes in this population and complex gene-gene and gene-environment interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.