ArticleNeurochemical research2012
Phospho-Rb mediating cell cycle reentry induces early apoptosis following oxygen-glucose deprivation in rat cortical neurons.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Review
- Stabilization of primary cilia reduces abortive cell cycle re-entry to protect injured adult CNS neurons from apoptosis.PloS one · 2019Article
- TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke.Frontiers in cellular neuroscience · 2018Article
- The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion.Experimental and therapeutic medicine · 2017Article
- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids.Development (Cambridge, England) · 2017Article
- Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex.Regenerative therapy · 2016Review
- Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke.Cell death & disease · 2015Article
- Cutting through the complexities of mTOR for the treatment of stroke.Current neurovascular research · 2014Review
- Article
- Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats.Journal of molecular histology · 2013Article
- Targeting disease through novel pathways of apoptosis and autophagy.Expert opinion on therapeutic targets · 2012Review
- Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin.Progress in neurobiology · 2012Review
- A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.Future neurology · 2012Article
- Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade.International journal of molecular sciences · 2012Review
- The retinoblastoma protein is essential for survival of postmitotic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Erythropoietin: new directions for the nervous system.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the relationship between cell cycle reentry and apoptosis in cultured cortical neurons following oxygen-glucose deprivation (OGD). We found that the percentage of neurons with BrdU uptake, TUNEL staining, and colocalized BrdU uptake and TUNEL staining was increased relative to control 6, 12 and 24 h after 1 h of OGD. The number of neurons with colocalized BrdU and TUNEL staining was decreased relative to the number of TUNEL-positive neurons at 24 h. The expression of phosphorylated retinoblastoma protein (phospho-Rb) was significantly increased 6, 12 and 24 h after OGD, parallel with the changes in BrdU uptake. Phospho-Rb and TUNEL staining were colocalized in neurons 6 and 12 h after OGD. This colocalization was strikingly decreased 24 h after OGD. Treatment with the cyclin-dependent kinase inhibitor roscovitine (100 μM) decreased the expression of phospho-Rb and reduced neuronal apoptosis in vitro. These results demonstrated that attempted cell cycle reentry with phosphorylation of Rb induce early apoptosis in neurons after OGD and there must be other mechanisms involved in the later stages of neuronal apoptosis besides cell cycle reentry. Phosphoralated Rb may be an important factor which closely associates aberrant cell cycle reentry with the early stages of neuronal apoptosis following ischemia/hypoxia in vitro, and pharmacological interventions for neuroprotection may be useful directed at this keypoint.
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Registered trials
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